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PMID: 14521516 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

Stem cells in normal breast development and breast cancer.

Cell proliferation ·Vol. 36 Suppl 1 ·2003-10-00 ·Pages 59-72

Dontu G, Al-Hajj M, Abdallah WM, Clarke MF, Wicha MS

Abstract

The main focus of this review is the role of mammary stem cells in normal breast development and carcinogenesis. We have developed a new in vitro culture system that permits, for the first time, the propagation of mammary stem and progenitor cells in an undifferentiated state, which should facilitate the elucidation of pathways that regulate normal mammary stem-cell self-renewal and differentiation. Furthermore, we propose a model in which transformation of stem cells, or early progenitor cells, results in carcinogenesis. A key event in this process is the deregulation of normal self-renewal in these cells. Transformed mammary stem or progenitor cells undergo aberrant differentiation processes that result in generation of the phenotypic heterogeneity found in human and rodent breast cancers. This phenotypic diversity is driven by a small subset of mammary tumour stem cells. We will discuss the important implications of this mammary tumour stem-cell model.

MeSH Terms
Animals Breast/cytology,growth & development Breast Neoplasms/pathology Humans Mammary Glands, Animal/cytology,growth & development Stem Cells/cytology
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Dontu Gabriela
Department of Internal Medicine, Hematology-Oncology, Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA. [email protected]
Al-Hajj Muhammad
Abdallah Wissam M
Clarke Michael F
Wicha Max S
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Article Info
Journal
Cell proliferation
Abbr.
Cell Prolif
ISSN
0960-7722
DOI
10.1046/j.1365-2184.36.s.1.6.x
Email
[email protected]
Published
2003-10-00
Pages
59-72
Language
English
Region
England
NLM ID
9105195
PMCID
PMC6495427
Subset
IM
Grants
ODCDC CDC HHS · CCA66233 · United States
External Links
PubMed source DOI: 10.1046/j.1365-2184.36.s.1.6.x PMC Full Text View journal details
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