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PMID: 14528264 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Regulating histone acetyltransferases and deacetylases.

EMBO reports ·Vol. 4 ·No. 10 ·2003-10-00 ·Pages 944-7

Legube G, Trouche D

Abstract

Histone acetyltransferases and histone deacetylases regulate the acetylation of histones and transcription factors, and in doing so have major roles in the control of cell fate. Many recent results have indicated that their function is strictly regulated in cells through the modulation of their levels, activity and availability for interaction with specific transcription factors. In this review, we present the various molecular mechanisms that bring about this tight regulation and discuss how these regulatory events influence cellular responses to environmental changes.

MeSH Terms
Acetyltransferases/metabolism Gene Expression Regulation, Enzymologic Histone Acetyltransferases Histone Deacetylases/metabolism Histones/metabolism Humans Nuclear Proteins/genetics,metabolism Protein Processing, Post-Translational Signal Transduction/physiology Trans-Activators/genetics,metabolism Transcription Factors/metabolism
Chemicals
Histones Nuclear Proteins Trans-Activators Transcription Factors Acetyltransferases Histone Acetyltransferases Histone Deacetylases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Legube Gaëlle
Laboratoire de Biologie Moléculaire des Eucaryotes, UMR 5099 Centre National de la Recherche Scientifique, Institut d'Exploration Fonctionnelle des Génomes, 118 Route de Narbonne, 31062 Toulouse Cedex, France.
Trouche Didier
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Article Info
Journal
EMBO reports
Abbr.
EMBO Rep
ISSN
1469-221X
DOI
10.1038/sj.embor.embor941
Published
2003-10-00
Pages
944-7
Language
English
Region
England
NLM ID
100963049
PMCID
PMC1326399
Subset
IM
External Links
PubMed source DOI: 10.1038/sj.embor.embor941 PMC Full Text View journal details
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