Biosynthesis of modified peptidoglycan precursors by vancomycin-resistant Enterococcus faecium.

FEMS microbiology letters ·Vol. 77 ·No. 1-3 ·1992-11-01 ·Pages 109-15

Allen NE, Hobbs JN, Richardson JM, Riggin RM

Abstract

In the presence of bacitracin, vancomycin-resistant Enterococcus faecium (vanA phenotype) accumulate UDP-N-acetylmuramyl(UDP-Mur-NAc)-tetrapeptide and a UDP-MurNAc-depsipentapeptide containing lactate substituted for the carboxy-terminal-D-alanine residue. In an in vitro peptidoglycan polymerization assay, the modified precursors function and confer resistance to vancomycin.

MeSH Terms

Amino Acid Sequence Drug Resistance, Microbial Enterococcus faecium/drug effects,metabolism Molecular Sequence Data Peptidoglycan/biosynthesis,chemistry Protein Precursors/biosynthesis,chemistry Uridine Diphosphate N-Acetylmuramic Acid/analogs & derivatives,biosynthesis,chemistry Vancomycin/pharmacology

Chemicals

Peptidoglycan Protein Precursors Uridine Diphosphate N-Acetylmuramic Acid UDP-N-acetylmuramic acid pentapeptide Vancomycin

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Allen N E

Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285.

Hobbs J N

Richardson J M

Riggin R M

Article Info

Journal

FEMS microbiology letters

Abbr.

FEMS Microbiol Lett

ISSN

0378-1097

DOI

10.1016/0378-1097(92)90140-j

Published

1992-11-01

Pages

109-15

Language

English

Region

England

NLM ID

7705721

Subset

External Links

PubMed source DOI: 10.1016/0378-1097(92)90140-j View journal details

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Biosynthesis of modified peptidoglycan precursors by vancomycin-resistant Enterococcus faecium.

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