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PMID: 14615545 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Inflammatory blockade restores adult hippocampal neurogenesis.

Science (New York, N.Y.) ·Vol. 302 ·No. 5651 ·2003-12-05 ·Pages 1760-5

Monje ML, Toda H, Palmer TD

Abstract

Cranial radiation therapy causes a progressive decline in cognitive function that is linked to impaired neurogenesis. Chronic inflammation accompanies radiation injury, suggesting that inflammatory processes may contribute to neural stem cell dysfunction. Here, we show that neuroinflammation alone inhibits neurogenesis and that inflammatory blockade with indomethacin, a common nonsteroidal anti-inflammatory drug, restores neurogenesis after endotoxin-induced inflammation and augments neurogenesis after cranial irradiation.

MeSH Terms

Animals Anti-Inflammatory Agents, Non-Steroidal/pharmacology Antigens, CD/metabolism Apoptosis Cell Differentiation Cells, Cultured Coculture Techniques Culture Media, Conditioned Cytokine Receptor gp130 Cytokines/physiology Dentate Gyrus/cytology,drug effects,physiology,radiation effects Female Gamma Rays Hippocampus/cytology,drug effects,physiology,radiation effects In Situ Nick-End Labeling Indomethacin/pharmacology Inflammation/drug therapy,physiopathology Interleukin-6/pharmacology,physiology Lipopolysaccharides/pharmacology Membrane Glycoproteins/metabolism Mice Microglia/physiology Mitotic Index Neurons/drug effects,physiology,radiation effects Rats Rats, Inbred F344 Receptors, Interleukin-6/metabolism Recombinant Proteins/pharmacology Signal Transduction Stem Cells/physiology

Chemicals

Anti-Inflammatory Agents, Non-Steroidal Antigens, CD Culture Media, Conditioned Cytokines Il6st protein, mouse Il6st protein, rat Interleukin-6 Lipopolysaccharides Membrane Glycoproteins Receptors, Interleukin-6 Recombinant Proteins Cytokine Receptor gp130 Indomethacin

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Monje Michelle L

Stanford University, Department of Neurosurgery, MSLS P309, Mail Code 5487, 1201 Welch Road, Stanford, CA 94305-5487, USA.

Toda Hiroki

Palmer Theo D

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

1095-9203

DOI

10.1126/science.1088417

Published

2003-12-05

Epub

2003-00-13

Pages

1760-5

Language

English

Region

United States

NLM ID

0404511

Subset

Grants

NINDS NIH HHS · F30 NS04696701 · United States

NIMH NIH HHS · MH20016-05 · United States

Corrections

CommentIn

PMID: 14657479

External Links

PubMed source DOI: 10.1126/science.1088417 View journal details

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Inflammatory blockade restores adult hippocampal neurogenesis.

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