Home LiteratureArticle Details
PMID: 14622402 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

From nose to lung: the regulation behind Streptococcus pneumoniae virulence factors.

Molecular microbiology ·Vol. 50 ·No. 4 ·2003-11-00 ·Pages 1103-10

Hava DL, LeMieux J, Camilli A

Abstract

Streptococcus pneumoniae probably possesses a redundant set of factors required for colonization of the nasopharynx and invasive disease, because of its strict relationship with its human host and relatively small genome size (approximately 2.1 Mb). Nevertheless, transcriptional regulation of genes encoding factors required for in vivo growth is predicted to be important on two fronts: in the transition from carriage to invasive disease and within different microniches of the nasopharynx. The importance of both serotype-specific and host tissue-specific virulence factors during infection and disease has been highlighted by the recent identification of novel virulence factors in this organism coupled with the release of complete genome sequences from two strains. These studies add to the foundation of knowledge of classical S. pneumoniae virulence factors such as polysaccharide capsule and pneumolysin, which have well-documented roles in pathogenesis.

MeSH Terms
Bacterial Proteins/genetics,metabolism Gene Expression Regulation, Bacterial Genome, Bacterial Humans Lung/microbiology Nose/microbiology Pneumococcal Infections/microbiology Streptococcus pneumoniae/genetics,metabolism,pathogenicity Virulence Factors/genetics,metabolism
Chemicals
Bacterial Proteins Virulence Factors
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Hava David L
Tufts University School of Medicine, Department of Molecular Biology and Microbiology, 136 Harrison Avenue, Boston, MA 02111, USA.
LeMieux Julianna
Camilli Andrew
References (45)
45 references, click to expand
  1. Relationship between phase variation in colony morphology, intrastrain variation in cell wall physiology, and nasopharyngeal colonization by Streptococcus pneumoniae.
    Infect Immun. 1996 Jun;64(6):2240-5 PMID: 8675333
  2. Regulation of competence for genetic transformation in Streptococcus pneumoniae by an auto-induced peptide pheromone and a two-component regulatory system.
    Mol Microbiol. 1996 Aug;21(4):853-62 PMID: 8878046
  3. Contribution of novel choline-binding proteins to adherence, colonization and immunogenicity of Streptococcus pneumoniae.
    Mol Microbiol. 1997 Sep;25(5):819-29 PMID: 9364908
  4. Identification of Staphylococcus aureus virulence genes in a murine model of bacteraemia using signature-tagged mutagenesis.
    Mol Microbiol. 1997 Oct;26(2):399-407 PMID: 9383163
  5. Association of intrastrain phase variation in quantity of capsular polysaccharide and teichoic acid with the virulence of Streptococcus pneumoniae.
    J Infect Dis. 1998 Feb;177(2):368-77 PMID: 9466523
  6. Large-scale identification of virulence genes from Streptococcus pneumoniae.
    Infect Immun. 1998 Dec;66(12):5620-9 PMID: 9826334
  7. Identification of a Streptococcus pneumoniae gene locus encoding proteins of an ABC phosphate transporter and a two-component regulatory system.
    J Bacteriol. 1999 Feb;181(4):1126-33 PMID: 9973337
  8. CtsR, a novel regulator of stress and heat shock response, controls clp and molecular chaperone gene expression in gram-positive bacteria.
    Mol Microbiol. 1999 Jan;31(1):117-31 PMID: 9987115
  9. Domain organization and molecular characterization of 13 two-component systems identified by genome sequencing of Streptococcus pneumoniae.
    Gene. 1999 Sep 3;237(1):223-34 PMID: 10524254
  10. Additive attenuation of virulence of Streptococcus pneumoniae by mutation of the genes encoding pneumolysin and other putative pneumococcal virulence proteins.
    Infect Immun. 2000 Jan;68(1):133-40 PMID: 10603379
  11. A genomic analysis of two-component signal transduction in Streptococcus pneumoniae.
    Mol Microbiol. 2000 Feb;35(3):566-76 PMID: 10672179
  12. Identification and analysis of bacterial virulence genes in vivo.
    Philos Trans R Soc Lond B Biol Sci. 2000 May 29;355(1397):613-22 PMID: 10874734
  13. Microarray-based identification of a novel Streptococcus pneumoniae regulon controlled by an autoinduced peptide.
    J Bacteriol. 2000 Sep;182(17):4696-703 PMID: 10940007
  14. Global analysis of transcription kinetics during competence development in Streptococcus pneumoniae using high density DNA arrays.
    Mol Microbiol. 2000 Jun;36(6):1279-92 PMID: 10931279
  15. Two-component signal transduction.
    Annu Rev Biochem. 2000;69:183-215 PMID: 10966457
  16. A functional genomic analysis of type 3 Streptococcus pneumoniae virulence.
    Mol Microbiol. 2001 May;40(3):555-71 PMID: 11359563
  17. Mosaic genes and mosaic chromosomes: intra- and interspecies genomic variation of Streptococcus pneumoniae.
    Infect Immun. 2001 Apr;69(4):2477-86 PMID: 11254610
  18. Identification of new genes involved in the virulence of Listeria monocytogenes by signature-tagged transposon mutagenesis.
    Infect Immun. 2001 Apr;69(4):2054-65 PMID: 11254558
  19. Differential fluorescence induction reveals Streptococcus pneumoniae loci regulated by competence stimulatory peptide.
    Mol Microbiol. 2001 Jan;39(1):126-35 PMID: 11123694
  20. Cross-regulation of competence pheromone production and export in the early control of transformation in Streptococcus pneumoniae.
    Mol Microbiol. 2000 Nov;38(4):867-78 PMID: 11115120
  21. Gene expression analysis of the Streptococcus pneumoniae competence regulons by use of DNA microarrays.
    J Bacteriol. 2000 Nov;182(21):6192-202 PMID: 11029442
  22. MgrA, an orthologue of Mga, Acts as a transcriptional repressor of the genes within the rlrA pathogenicity islet in Streptococcus pneumoniae.
    J Bacteriol. 2003 Nov;185(22):6640-7 PMID: 14594838
  23. Histidine kinases and response regulator proteins in two-component signaling systems.
    Trends Biochem Sci. 2001 Jun;26(6):369-76 PMID: 11406410
  24. Complete genome sequence of a virulent isolate of Streptococcus pneumoniae.
    Science. 2001 Jul 20;293(5529):498-506 PMID: 11463916
  25. Genome of the bacterium Streptococcus pneumoniae strain R6.
    J Bacteriol. 2001 Oct;183(19):5709-17 PMID: 11544234
  26. Regulation of Streptococcus pneumoniae clp genes and their role in competence development and stress survival.
    J Bacteriol. 2001 Dec;183(24):7295-307 PMID: 11717289
  27. Differential fluorescence induction analysis of Streptococcus pneumoniae identifies genes involved in pathogenesis.
    Infect Immun. 2002 Mar;70(3):1422-33 PMID: 11854229
  28. Two DNA-binding domains of Mga are required for virulence gene activation in the group A streptococcus.
    Mol Microbiol. 2002 Mar;43(6):1591-601 PMID: 11952907
  29. Microarray-based identification of htrA, a Streptococcus pneumoniae gene that is regulated by the CiaRH two-component system and contributes to nasopharyngeal colonization.
    Infect Immun. 2002 Aug;70(8):4059-67 PMID: 12117912
  30. Extracellular-peptide control of competence for genetic transformation in Streptococcus pneumoniae.
    Front Biosci. 2002 Aug 1;7:d1798-814 PMID: 12133809
  31. Short-sequence tandem and nontandem DNA repeats and endogenous hydrogen peroxide production contribute to genetic instability of Streptococcus pneumoniae.
    J Bacteriol. 2002 Aug;184(16):4392-9 PMID: 12142409
  32. Large-scale identification of serotype 4 Streptococcus pneumoniae virulence factors.
    Mol Microbiol. 2002 Sep;45(5):1389-406 PMID: 12207705
  33. Bacteriocins: evolution, ecology, and application.
    Annu Rev Microbiol. 2002;56:117-37 PMID: 12142491
  34. Role of RegM, a homologue of the catabolite repressor protein CcpA, in the virulence of Streptococcus pneumoniae.
    Infect Immun. 2002 Oct;70(10):5454-61 PMID: 12228270
  35. Cell to cell communication by autoinducing peptides in gram-positive bacteria.
    Antonie Van Leeuwenhoek. 2002 Aug;81(1-4):233-43 PMID: 12448722
  36. The Streptococcus pneumoniae cia regulon: CiaR target sites and transcription profile analysis.
    J Bacteriol. 2003 Jan;185(1):60-70 PMID: 12486041
  37. Transcriptional regulation in the Streptococcus pneumoniae rlrA pathogenicity islet by RlrA.
    J Bacteriol. 2003 Jan;185(2):413-21 PMID: 12511486
  38. RegR, a global LacI/GalR family regulator, modulates virulence and competence in Streptococcus pneumoniae.
    Infect Immun. 2003 May;71(5):2615-25 PMID: 12704136
  39. A two-component signal-transducing system is involved in competence and penicillin susceptibility in laboratory mutants of Streptococcus pneumoniae.
    Mol Microbiol. 1994 May;12(3):505-15 PMID: 8065267
  40. The identification of rofA, a positive-acting regulatory component of prtF expression: use of an m gamma delta-based shuttle mutagenesis strategy in Streptococcus pyogenes.
    Mol Microbiol. 1994 Feb;11(4):671-84 PMID: 8196542
  41. Phase variation in pneumococcal opacity: relationship between colonial morphology and nasopharyngeal colonization.
    Infect Immun. 1994 Jun;62(6):2582-9 PMID: 8188381
  42. Cloning and nucleotide sequence of the Streptococcus pneumoniae hyaluronidase gene and purification of the enzyme from recombinant Escherichia coli.
    Infect Immun. 1994 Mar;62(3):1101-8 PMID: 8112843
  43. Identification of Streptococcus agalactiae virulence genes in the neonatal rat sepsis model using signature-tagged mutagenesis.
    Mol Microbiol. 2000 Sep;37(6):1444-55 PMID: 10998175
  44. Identification of a gene that regulates expression of M protein, the major virulence determinant of group A streptococci.
    Proc Natl Acad Sci U S A. 1987 Dec;84(23):8677-81 PMID: 2446327
  45. Molecular analysis of the pathogenicity of Streptococcus pneumoniae: the role of pneumococcal proteins.
    Annu Rev Microbiol. 1993;47:89-115 PMID: 7903033
Article Info
Journal
Molecular microbiology
Abbr.
Mol Microbiol
ISSN
0950-382X
DOI
10.1046/j.1365-2958.2003.03764.x
Published
2003-11-00
Pages
1103-10
Language
English
Region
England
NLM ID
8712028
PMCID
PMC2791164
Subset
IM
Grants
NIAID NIH HHS · R21 AI052374-01 · United States
NIAID NIH HHS · AI52374 · United States
External Links
PubMed source DOI: 10.1046/j.1365-2958.2003.03764.x PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2