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PMID: 146331 Published · ppublish ger Clinical Trial English Abstract Journal Article Randomized Controlled Trial

[Combination chemotherapy in patients with disseminated bronchogenic carcinoma (author's transl)].

Kombinationschemotherapie bei Patienten mit metastasiertem Bronchialcarcinom.

Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology ·Vol. 90 ·No. 3 ·1977-12-15 ·Pages 301-6

Gropp C, Havemann K, Gassel WD, Hess F, Prignitz R, Schmidt M, Sodomann CP

Abstract

49 patients with disseminated bronchogenic carcinoma (small cell, 16;squamous cell, 17;large cell, 12;adeno, 4) were treated with a combination of adriamycin, cyclophosphamide, vincristine and DTIC. In a randomized series (21 patients) chemotherapy alone was compared to chemotherapy plus heparin. Partial remission was achieved in 8 patients with small cell carcinoma, in 5 patients with large carcinoma and in 2 patients with squamous cell carcinoma. The survival of patients who responded to therapy was greater than the survival of patients who did not respond to therapy. The duration of remission and the survival time was not longer in patients who had additional heparin therapy.

MeSH Terms

Antineoplastic Agents/therapeutic use Carcinoma, Bronchogenic/drug therapy Cyclophosphamide/therapeutic use Doxorubicin/therapeutic use Drug Therapy, Combination Humans Lung Neoplasms/drug therapy Neoplasm Metastasis/drug therapy Vincristine/therapeutic use

Chemicals

Antineoplastic Agents Vincristine Doxorubicin Cyclophosphamide

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Gropp C

Havemann K

Gassel W D

Hess F

Prignitz R

Schmidt M

Sodomann C P

References (14)

14 references, click to expand

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Article Info

Journal

Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology

Abbr.

Z Krebsforsch Klin Onkol Cancer Res Clin Oncol

ISSN

0084-5353

DOI

10.1007/BF00284303

Published

1977-12-15

Pages

301-6

Language

ger

Region

Germany

NLM ID

1276653

Subset

External Links

PubMed source DOI: 10.1007/BF00284303

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[Combination chemotherapy in patients with disseminated bronchogenic carcinoma (author's transl)].

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