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PMID: 14634638 Published · ppublish English Journal Article Review

The nature and identification of quantitative trait loci: a community's view.

Nature reviews. Genetics ·Vol. 4 ·No. 11 ·2003-11-00 ·Pages 911-6

Abiola O, Angel JM, Avner P, Bachmanov AA, Belknap JK, Bennett B, Blankenhorn EP, Blizard DA, Bolivar V, Brockmann GA, Buck KJ, Bureau JF, Casley WL, Chesler EJ, Cheverud JM, Churchill GA, Cook M, Crabbe JC, Crusio WE, Darvasi A, de Haan G, Dermant P, Doerge RW, Elliot RW, Farber CR, Flaherty L, Flint J, Gershenfeld H, Gibson JP, Gu J, Gu W, Himmelbauer H, Hitzemann R, Hsu HC, Hunter K, Iraqi FF, Jansen RC, Johnson TE, Jones BC, Kempermann G, Lammert F, Lu L, Manly KF, Matthews DB, Medrano JF, Mehrabian M, Mittlemann G, Mock BA, Mogil JS, Montagutelli X, Morahan G, Mountz JD, Nagase H, Nowakowski RS, O'Hara BF, Osadchuk AV, Paigen B, Palmer AA, Peirce JL, Pomp D, Rosemann M, Rosen GD, Schalkwyk LC, Seltzer Z, Settle S, Shimomura K, Shou S, Sikela JM, Siracusa LD, Spearow JL, Teuscher C, Threadgill DW, Toth LA, Toye AA, Vadasz C, Van Zant G, Wakeland E, Williams RW, Zhang HG, Zou F, Complex Trait Consortium

Abstract

This white paper by eighty members of the Complex Trait Consortium presents a community's view on the approaches and statistical analyses that are needed for the identification of genetic loci that determine quantitative traits. Quantitative trait loci (QTLs) can be identified in several ways, but is there a definitive test of whether a candidate locus actually corresponds to a specific QTL?

Keywords
Non-programmatic
MeSH Terms
Animals Animals, Genetically Modified Chromosome Mapping/standards Humans Quantitative Trait Loci
Authors & Affiliations
81 authors, click to expand affiliations / ORCID
Abiola Oduola
Angel Joe M
Avner Philip
Bachmanov Alexander A
Belknap John K
Bennett Beth
Blankenhorn Elizabeth P
Blizard David A
Bolivar Valerie
Brockmann Gundrun A
Buck Kari J
Bureau Jean-Francoise
Casley William L
Chesler Elissa J
Cheverud James M
Churchill Gary A
Cook Melloni
Crabbe John C
Crusio Wim E
Darvasi Ariel
de Haan Gerald
Dermant Peter
Doerge R W
Elliot Rosemary W
Farber Charles R
Flaherty Lorraine
Flint Jonathan
Gershenfeld Howard
Gibson John P
Gu Jing
Gu Weikuan
Himmelbauer Heinz
Hitzemann Robert
Hsu Hui-Chen
Hunter Kent
Iraqi Fuad F
Jansen Ritsert C
Johnson Thomas E
Jones Byron C
Kempermann Gerd
Lammert Frank
Lu Lu
Manly Kenneth F
Matthews Douglas B
Medrano Juan F
Mehrabian Margarete
Mittlemann Guy
Mock Beverly A
Mogil Jeffrey S
Montagutelli Xavier
Morahan Grant
Mountz John D
Nagase Hiroki
Nowakowski Richard S
O'Hara Bruce F
Osadchuk Alexander V
Paigen Beverly
Palmer Abraham A
Peirce Jeremy L
Pomp Daniel
Rosemann Michael
Rosen Glenn D
Schalkwyk Leonard C
Seltzer Ze'ev
Settle Stephen
Shimomura Kazuhiro
Shou Siming
Sikela James M
Siracusa Linda D
Spearow Jimmy L
Teuscher Cory
Threadgill David W
Toth Linda A
Toye Ayo A
Vadasz Csaba
Van Zant Gary
Wakeland Edward
Williams Robert W
Zhang Huang-Ge
Zou Fei
Complex Trait Consortium
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Article Info
Journal
Nature reviews. Genetics
Abbr.
Nat Rev Genet
ISSN
1471-0056
DOI
10.1038/nrg1206
Published
2003-11-00
Pages
911-6
Language
English
Region
England
NLM ID
100962779
PMCID
PMC2063446
Subset
IM
Grants
NIDCD NIH HHS · R03 DC003854-02 · United States
NIAAA NIH HHS · R01 AA011028 · United States
NIAAA NIH HHS · R01 AA011028-08 · United States
NIDCD NIH HHS · R01 DC000882 · United States
NIDCD NIH HHS · R01 DC000882-24 · United States
NIAAA NIH HHS · P60 AA010760 · United States
External Links
PubMed source DOI: 10.1038/nrg1206 PMC Full Text View journal details
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