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PMID: 14635796 Published · ppublish English Journal Article Review

NF-kappaB in mammary gland development and breast cancer.

Journal of mammary gland biology and neoplasia ·Vol. 8 ·No. 2 ·2003-04-00 ·Pages 215-23

Cao Y, Karin M

Abstract

Nuclear factor of kappaB (NF-kappaB) is a group of sequence-specific transcription factors that is best known as a key regulator of the inflammatory and innate immune responses. Recent studies of genetically engineered mice have clearly indicated that NF-kappaB is also required for proper organogenesis of several epithelial tissues, including the mammary gland. Mice have shown severe lactation deficiency when NF-kappaB activation is specifically blocked in the mammary gland. In addition, there are strong suggestions that NF-kappaB may play an important role in the etiology of breast cancer. Elevated NF-kappaB DNA-binding activity is detected in both mammary carcinoma cell lines and primary human breast cancer tissues.

MeSH Terms
Animals Breast Neoplasms/metabolism Cell Line, Tumor Cyclin D1/biosynthesis Female Humans I-kappa B Kinase Mammary Glands, Animal/metabolism Mammary Glands, Human/metabolism Mammary Neoplasms, Animal/metabolism Mice Models, Biological NF-kappa B/metabolism,physiology Phosphorylation Pregnancy Protein Serine-Threonine Kinases/biosynthesis Signal Transduction
Chemicals
NF-kappa B Cyclin D1 Protein Serine-Threonine Kinases CHUK protein, human Chuk protein, mouse I-kappa B Kinase IKBKB protein, human IKBKE protein, human Ikbkb protein, mouse Ikbke protein, mouse
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Cao Yixue
Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA.
Karin Michael
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Article Info
Journal
Journal of mammary gland biology and neoplasia
Abbr.
J Mammary Gland Biol Neoplasia
ISSN
1083-3021
DOI
10.1023/a:1025905008934
Published
2003-04-00
Pages
215-23
Language
English
Region
United States
NLM ID
9601804
Subset
IM
External Links
PubMed source DOI: 10.1023/a:1025905008934 View journal details
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