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PMID: 1466599 Published · ppublish English Comparative Study Journal Article

Increased concentrations of nitrite in synovial fluid and serum samples suggest increased nitric oxide synthesis in rheumatic diseases.

Annals of the rheumatic diseases ·Vol. 51 ·No. 11 ·1992-11-00 ·Pages 1219-22

Farrell AJ, Blake DR, Palmer RM, Moncada S

Abstract

Cytokines induce nitric oxide synthesis by endothelial cells, macrophages and polymorphonuclear leucocytes, indicating a role for nitric oxide in inflammatory processes. Nitric oxide production was therefore measured indirectly as nitrite in serum and synovial fluid samples from patients with rheumatoid arthritis (RA) and osteoarthritis (OA) together with serum samples from healthy volunteers matched for age and sex. Serum nitrite concentrations in patients with RA and OA were significantly higher than in controls. In both disease groups synovial fluid nitrite was significantly higher than serum nitrite, implying nitric oxide synthesis by the synovium. Serum and synovial fluid nitrite concentrations in RA were also significantly higher than those in OA. These data show increased nitric oxide production in RA and OA and suggest a role for nitric oxide as an inflammatory mediator in rheumatic diseases.

MeSH Terms
Arthritis, Rheumatoid/metabolism Female Humans Male Middle Aged Nitric Oxide/metabolism Nitrites/analysis,blood Osteoarthritis/metabolism Rheumatic Diseases/metabolism Synovial Fluid/chemistry,metabolism
Chemicals
Nitrites Nitric Oxide
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Farrell A J
Inflammation Research Group, London Hospital Medical College, Whitechapel, United Kingdom.
Blake D R
Palmer R M
Moncada S
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Article Info
Journal
Annals of the rheumatic diseases
Abbr.
Ann Rheum Dis
ISSN
0003-4967
DOI
10.1136/ard.51.11.1219
Published
1992-11-00
Pages
1219-22
Language
English
Region
England
NLM ID
0372355
PMCID
PMC1012459
Subset
IM
External Links
PubMed source DOI: 10.1136/ard.51.11.1219 PMC Full Text View journal details
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