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PMID: 1466750 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

A strategy to improve the efficacy of vaccination against tuberculosis and leprosy.

Immunology today ·Vol. 13 ·No. 9 ·1992-09-00 ·Pages 342-5

Bretscher PA

Abstract

The pathogens responsible for leprosy, tuberculosis and the leishmaniases can induce different classes of immunity, but protection is provided only by a cell-mediated response. Here, Peter Bretscher proposes a strategy to achieve an immunological imprint that ensures a stable cell-mediated response upon natural infection.

MeSH Terms

Animals BCG Vaccine/administration & dosage,immunology Bacterial Vaccines/administration & dosage,immunology Disease Susceptibility/immunology Dose-Response Relationship, Immunologic Genetic Predisposition to Disease Humans Hypersensitivity, Delayed/immunology Immunity, Cellular Immunity, Innate/genetics,immunology Leishmania tropica/immunology Leishmaniasis, Cutaneous/immunology,parasitology Leprosy/epidemiology,immunology,prevention & control Mice Mice, Inbred BALB C/immunology,parasitology Mycobacterium bovis/classification,immunology Mycobacterium leprae/immunology Mycobacterium tuberculosis/immunology Rats Tuberculosis/epidemiology,immunology,prevention & control Vaccination

Chemicals

BCG Vaccine Bacterial Vaccines

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Bretscher P A

Dept of Microbiology, University of Saskatchewan, Saskatoon, Canada.

Article Info

Journal

Immunology today

Abbr.

Immunol Today

ISSN

0167-5699

DOI

10.1016/0167-5699(92)90168-7

Published

1992-09-00

Pages

342-5

Language

English

Region

England

NLM ID

8008346

Subset

External Links

PubMed source DOI: 10.1016/0167-5699(92)90168-7

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A strategy to improve the efficacy of vaccination against tuberculosis and leprosy.

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