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PMID: 14681373 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

ProTherm, version 4.0: thermodynamic database for proteins and mutants.

Nucleic acids research ·Vol. 32 ·No. Database issue ·2004-01-01 ·Pages D120-1

Bava KA, Gromiha MM, Uedaira H, Kitajima K, Sarai A

Abstract

Release 4.0 of ProTherm, thermodynamic database for proteins and mutants, contains approximately 14,500 numerical data (approximately 450% of the first version) of several thermodynamic parameters along with experimental methods and conditions, and structural, functional and literature information. The sequence and structural information of proteins is connected with thermodynamic data through links between entries in Protein Data Bank, Protein Information Resource and SWISS-PROT and the data in ProTherm. We have separated the Gibbs free energy change obtained at extrapolated temperature from the data on denaturation temperature measured by the thermal denaturation method. We have added the statistics of amino acid replacements and links to homologous structures to each protein. Further, we have improved the search and display options to enhance search capability through the web interface. ProTherm is freely available at http://gibk26. bse.kyutech.ac.jp/jouhou/Protherm/protherm.html.

MeSH Terms
Animals Databases, Protein Humans Internet Mutation/genetics Proteins/chemistry,genetics Structure-Activity Relationship Temperature Thermodynamics
Chemicals
Proteins
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Bava K Abdulla
Department of Biochemical Engineering and Science, Kyushu Institute of Technology (KIT), 680-4 Kawazu, Iizuka, 820-8502, Japan.
Gromiha M Michael
Uedaira Hatsuho
Kitajima Koji
Sarai Akinori
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14 references, click to expand
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
1362-4962
DOI
10.1093/nar/gkh082
Published
2004-01-01
Pages
D120-1
Language
English
Region
England
NLM ID
0411011
PMCID
PMC308816
Subset
IM
External Links
PubMed source DOI: 10.1093/nar/gkh082 PMC Full Text View journal details
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