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PMID: 14705119 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

DJ-1 colocalizes with tau inclusions: a link between parkinsonism and dementia.

Annals of neurology ·Vol. 55 ·No. 1 ·2004-01-00 ·Pages 113-8

Rizzu P, Hinkle DA, Zhukareva V, Bonifati V, Severijnen LA, Martinez D, Ravid R, Kamphorst W, Eberwine JH, Lee VM, Trojanowski JQ, Heutink P

Abstract

Two novel mutations recently have been identified in the DJ-1 gene that cause a new form of autosomal recessive, early-onset parkinsonism. Because the pathological role of this protein is unknown, we examined the issue here and report the colocalization of DJ-1 protein within a subset of pathological tau inclusions in a diverse group of neurodegenerative disorders known as tauopathies. Our study extends the view that different neurodegenerative diseases may have similar pathological mechanisms, and that these processes likely include DJ-1.

MeSH Terms
Aged Aged, 80 and over Animals Brain/metabolism,pathology COS Cells Chlorocebus aethiops Dementia/metabolism,pathology HeLa Cells Humans Immunoblotting Immunohistochemistry Inclusion Bodies/metabolism,ultrastructure Intracellular Signaling Peptides and Proteins Middle Aged Neurofibrillary Tangles/metabolism,pathology Oncogene Proteins/genetics,metabolism Parkinsonian Disorders/metabolism,pathology Protein Deglycase DJ-1 Transfection tau Proteins/metabolism
Chemicals
Intracellular Signaling Peptides and Proteins Oncogene Proteins tau Proteins PARK7 protein, human Protein Deglycase DJ-1
Authors & Affiliations
12 authors, click to expand affiliations / ORCID
Rizzu Patrizia
Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands.
Hinkle David A
Zhukareva Victoria
Bonifati Vincenzo
Severijnen Lies-Anne
Martinez Daniel
Ravid Rivka
Kamphorst Wouter
Eberwine James H
Lee Virginia M-Y
Trojanowski John Q
Heutink Peter
Article Info
Journal
Annals of neurology
Abbr.
Ann Neurol
ISSN
0364-5134
DOI
10.1002/ana.10782
Published
2004-01-00
Pages
113-8
Language
English
Region
United States
NLM ID
7707449
Subset
IM
Grants
PHS HHS · A610125 · United States
PHS HHS · A617586 · United States
PHS HHS · A69900 · United States
External Links
PubMed source DOI: 10.1002/ana.10782 View journal details
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