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PMID: 14708011 Published · ppublish English Journal Article Review

Ageing, repetitive genomes and DNA damage.

Nature reviews. Molecular cell biology ·Vol. 5 ·No. 1 ·2004-01-00 ·Pages 69-75

Lieber MR, Karanjawala ZE

Abstract

The mitochondrial production of reactive oxygen species is inversely proportional to longevity in animals. A key question now is, which molecules, among those that are oxidized, affect the lifespan of the organism most significantly?

MeSH Terms
Aging/genetics Animals DNA Damage/genetics Humans Longevity Mice Mitochondria/genetics,physiology Reactive Oxygen Species Repetitive Sequences, Nucleic Acid/genetics
Chemicals
Reactive Oxygen Species
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Lieber Michael R
University of Southern California Norris Comprehensive Cancer Center, Room 5428, Department of Pathology, 1441 Eastlake Avenue, MC9176, Los Angeles, California 90033, USA. [email protected]
Karanjawala Zarir E
Article Info
Journal
Nature reviews. Molecular cell biology
Abbr.
Nat Rev Mol Cell Biol
ISSN
1471-0072
DOI
10.1038/nrm1281
Email
[email protected]
Published
2004-01-00
Pages
69-75
Language
English
Region
England
NLM ID
100962782
Subset
IM
External Links
PubMed source DOI: 10.1038/nrm1281 View journal details
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