Immune activation: death, danger and dendritic cells.

Current biology : CB ·Vol. 14 ·No. 1 ·2004-01-06 ·Pages R30-2

Pulendran B

Abstract

Dendritic cells are critical for host immunity, and sense microbes with pathogen recognition receptors. New evidence indicates that these cells also sense uric acid crystals in dead cells, suggesting that the immune system is conscious not only of pathogens, but also of death and danger.

MeSH Terms

Cell Death/immunology Dendritic Cells/immunology,metabolism Humans Models, Immunological Self Tolerance/immunology T-Lymphocytes/immunology Uric Acid/immunology,metabolism

Chemicals

Uric Acid

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Pulendran Bali

Emory Vaccine Center, 954 Gatewood Road, Atlanta, Georgia 30329, USA. [email protected]

Article Info

Journal

Current biology : CB

Abbr.

Curr Biol

ISSN

0960-9822

DOI

10.1016/j.cub.2003.12.020

[email protected]

Published

2004-01-06

Pages

R30-2

Language

English

Region

England

NLM ID

9107782

Subset

External Links

PubMed source DOI: 10.1016/j.cub.2003.12.020 View journal details

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