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PMID: 14722772 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

The SLC4 family of HCO 3 - transporters.

Pflugers Archiv : European journal of physiology ·Vol. 447 ·No. 5 ·2004-02-00 ·Pages 495-509

Romero MF, Fulton CM, Boron WF

Abstract

The SLC4 family consists of ten genes. All appear to encode integral membrane proteins with very similar hydropathy plots-consistent with the presence of 10-14 transmembrane segments. At least eight SLC4 members encode proteins that transport HCO(3)(-) (or a related species, such as CO(3)(2-)) across the plasma membrane. Functionally, these eight proteins fall into two major groups: three Cl-HCO(3) exchangers (AE1-3) and five Na(+)-coupled HCO(3)(-) transporters (NBCe1, NBCe2, NBCn1, NDCBE, NCBE). Two of the Na(+)-coupled HCO(3)(- )transporters (NBCe1, NBCe2) are electrogenic; the other three Na(+)-coupled HCO(3)(-) transporters and all three AEs are electroneutral. At least NDCBE transports Cl(-) in addition to Na(+) and HCO(3)(-). Whether NCBE transports Cl(-)-in addition to Na(+) and HCO(3)(-)-is unsettled. In addition, two other SLC4 members (AE4 and BTR1) do not yet have a firmly established function; on the basis of homology, they fall between the two major groups. A characteristic of many, though not all, SLC4 members is inhibition by 4,4'-diisothiocyanatostilbene-2,2'-disulfonate (DIDS). SLC4 gene products play important roles in the carriage of CO(2) by erythrocytes, the absorption or secretion of H(+) or HCO(3)(-) by several epithelia, as well as the regulation of cell volume and intracellular pH.

MeSH Terms
Animals Bicarbonates/metabolism Biological Transport/physiology Chloride-Bicarbonate Antiporters/physiology Chlorides/metabolism Humans Multigene Family/physiology Sodium/metabolism Sodium-Bicarbonate Symporters/physiology
Chemicals
Bicarbonates Chloride-Bicarbonate Antiporters Chlorides Sodium-Bicarbonate Symporters Sodium
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Romero Michael F
Departments of Physiology and Biophysics and Pharmacology, Case Western Reserve University School of Medicine, Cleveland, OH 44106-4970, USA. [email protected]
Fulton Christiaan M
Boron Walter F
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Article Info
Journal
Pflugers Archiv : European journal of physiology
Abbr.
Pflugers Arch
ISSN
0031-6768
DOI
10.1007/s00424-003-1180-2
Email
[email protected]
Published
2004-02-00
Epub
2004-00-14
Pages
495-509
Language
English
Region
Germany
NLM ID
0154720
Subset
IM
Grants
NIDDK NIH HHS · DK-30344 · United States
NIDDK NIH HHS · DK-56218 · United States
NICHD NIH HHS · HD-32573 · United States
NINDS NIH HHS · NS-18400 · United States
External Links
PubMed source DOI: 10.1007/s00424-003-1180-2 View journal details
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