Two of the most challenging mysteries of morphogenesis are how cells receive positional information from neighbouring cells and how receipt of this information triggers events that initiate cell differentiation. The concept that the cytoskeleton and éxocellular matrix' (ECM) form an interactive scaffold for perception and transduction of positional information is relatively new. Research is beginning to indicate that a continuous cytoskeleton-ECM scaffold may be a feature of all eukaryotic cells and that many of the molecules participating in this structure may be shared by plants, fungi and animals.
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