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PMID: 14732906 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Joint analysis of the DRD5 marker concludes association with attention-deficit/hyperactivity disorder confined to the predominantly inattentive and combined subtypes.

American journal of human genetics ·Vol. 74 ·No. 2 ·2004-02-00 ·Pages 348-56

Lowe N, Kirley A, Hawi Z, Sham P, Wickham H, Kratochvil CJ, Smith SD, Lee SY, Levy F, Kent L, Middle F, Rohde LA, Roman T, Tahir E, Yazgan Y, Asherson P, Mill J, Thapar A, Payton A, Todd RD, Stephens T, Ebstein RP, Manor I, Barr CL, Wigg KG, Sinke RJ, Buitelaar JK, Smalley SL, Nelson SF, Biederman J, Faraone SV, Gill M

Abstract

Attention-deficit/hyperactivity disorder (ADHD) is a highly heritable, heterogeneous disorder of early onset, consisting of a triad of symptoms: inattention, hyperactivity, and impulsivity. The disorder has a significant genetic component, and theories of etiology include abnormalities in the dopaminergic system, with DRD4, DAT1, SNAP25, and DRD5 being implicated as major susceptibility genes. An initial report of association between ADHD and the common 148-bp allele of a microsatellite marker located 18.5 kb from the DRD5 gene has been followed by several studies showing nonsignificant trends toward association with the same allele. To establish the postulated association of the (CA)(n) repeat with ADHD, we collected genotypic information from 14 independent samples of probands and their parents, analyzed them individually and, in the absence of heterogeneity, analyzed them as a joint sample. The joint analysis showed association with the DRD5 locus (P=.00005; odds ratio 1.24; 95% confidence interval 1.12-1.38). This association appears to be confined to the predominantly inattentive and combined clinical subtypes.

MeSH Terms
Attention Deficit Disorder with Hyperactivity/classification,genetics Female Genetic Markers Humans Male Odds Ratio
Chemicals
Genetic Markers
Authors & Affiliations
32 authors, click to expand affiliations / ORCID
Lowe Naomi
Department of Genetics, Trinity College, Dublin 2, Ireland. [email protected]
Kirley Aiveen
Hawi Ziarih
Sham Pak
Wickham Harvey
Kratochvil Christopher J
Smith Shelley D
Lee Saretta Y
Levy Florence
Kent Lindsey
Middle Fiona
Rohde Luis A
Roman Tatiana
Tahir Eda
Yazgan Yanke
Asherson Philip
Mill Jonathan
Thapar Anita
Payton Antony
Todd Richard D
Stephens Timothy
Ebstein Richard P
Manor Iris
Barr Cathy L
Wigg Karen G
Sinke Richard J
Buitelaar Jan K
Smalley Susan L
Nelson Stan F
Biederman Joseph
Faraone Stephen V
Gill Michael
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Article Info
Journal
American journal of human genetics
Abbr.
Am J Hum Genet
ISSN
0002-9297
DOI
10.1086/381561
Email
[email protected]
Published
2004-02-00
Epub
2004-00-19
Pages
348-56
Language
English
Region
United States
NLM ID
0370475
PMCID
PMC1181932
Subset
IM
Grants
NICHD NIH HHS · R01 HD37694 · United States
NIMH NIH HHS · MH58277 · United States
NICHD NIH HHS · P50 HD027802 · United States
NIMH NIH HHS · R01 MH52812 · United States
NICHD NIH HHS · R01 HD037999 · United States
NIMH NIH HHS · R01 MH058277 · United States
NINDS NIH HHS · R01 NS43762 · United States
NIMH NIH HHS · R13 MH059126 · United States
NICHD NIH HHS · R01 HD036317 · United States
NINDS NIH HHS · R01 NS043762 · United States
NICHD NIH HHS · R01 HD037694 · United States
NIMH NIH HHS · R01 MH052813 · United States
NICHD NIH HHS · R01 HD36317 · United States
NIMH NIH HHS · R13 MH59126 · United States
NICHD NIH HHS · R01 HD37999 · United States
NIMH NIH HHS · R01 MH050657 · United States
External Links
PubMed source DOI: 10.1086/381561 PMC Full Text View journal details
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