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PMID: 14733921 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Direct reciprocal effects of resistin and adiponectin on vascular endothelial cells: a new insight into adipocytokine-endothelial cell interactions.

Biochemical and biophysical research communications ·Vol. 314 ·No. 2 ·2004-02-06 ·Pages 415-9

Kawanami D, Maemura K, Takeda N, Harada T, Nojiri T, Imai Y, Manabe I, Utsunomiya K, Nagai R

Abstract

Resistin is an adipocytokine which plays a role in the development of insulin resistance. In this study, we investigated the direct effect of resistin on vascular endothelial cells. Resistin induced the expression of adhesion molecules such as VCAM-1 and ICAM-1, and long pentraxin 3, a marker of inflammation. The induction of VCAM-1 by resistin was inhibited partially by pitavastatin. Moreover, the induction of VCAM-1 and ICAM-1 by resistin was inhibited by adiponectin, an adipocytokine that improves insulin resistance. Taken together, these results suggest that the balance in the concentrations of adipocytokines such as resistin and adiponectin determines the inflammation status of vasculature, and in turn the progress of atherosclerosis.

MeSH Terms

Adipocytes/metabolism Adiponectin Animals Arteriosclerosis/pathology Blotting, Northern Blotting, Western C-Reactive Protein/metabolism Cell Communication Cells, Cultured Cytokines/metabolism Dose-Response Relationship, Drug Endothelial Cells/metabolism Genes, Reporter Hormones, Ectopic/physiology Humans Insulin Resistance Intercellular Adhesion Molecule-1/metabolism Intercellular Signaling Peptides and Proteins Mice NF-kappa B/metabolism Proteins/metabolism,physiology Quinolines/metabolism RNA, Messenger/metabolism Resistin Serum Amyloid P-Component/metabolism Time Factors Transfection Vascular Cell Adhesion Molecule-1/metabolism

Chemicals

Adiponectin Cytokines Hormones, Ectopic Intercellular Signaling Peptides and Proteins NF-kappa B Proteins Quinolines RETN protein, human RNA, Messenger Resistin Retn protein, mouse Serum Amyloid P-Component Vascular Cell Adhesion Molecule-1 Intercellular Adhesion Molecule-1 PTX3 protein C-Reactive Protein pitavastatin

Authors & Affiliations

9 authors, click to expand affiliations / ORCID

Kawanami Daiji

Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan.

Maemura Koji

Takeda Norihiko

Harada Tomohiro

Nojiri Takefumi

Imai Yasushi

Manabe Ichiro

Utsunomiya Kazunori

Nagai Ryozo

Article Info

Journal

Biochemical and biophysical research communications

Abbr.

Biochem Biophys Res Commun

ISSN

0006-291X

DOI

10.1016/j.bbrc.2003.12.104

Published

2004-02-06

Pages

415-9

Language

English

Region

United States

NLM ID

0372516

Subset

External Links

PubMed source DOI: 10.1016/j.bbrc.2003.12.104 View journal details

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Direct reciprocal effects of resistin and adiponectin on vascular endothelial cells: a new insight into adipocytokine-endothelial cell interactions.

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