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PMID: 14742564 Published · ppublish English Journal Article

Type III secretion: a virulence factor delivery system essential for the pathogenicity of Burkholderia mallei.

Infection and immunity ·Vol. 72 ·No. 2 ·2004-02-00 ·Pages 1150-4

Ulrich RL, DeShazer D

Abstract

By creating mutations in the Burkholderia mallei ATCC 23344 animal pathogen-like type III secretion system (TTSS), this study analyzes the correlation between type III secretion and the pathogenicity of ATCC 23344 in vivo. Mutagenesis demonstrated that a functional TTSS was required for the full pathogenicity of ATCC 23344 in the BALB/c mouse and Syrian hamster models of infection. However, vaccination with each mutant failed to elicit a protective immunity against challenge with wild-type ATCC 23344.

MeSH Terms
Animals Burkholderia mallei/immunology,metabolism,pathogenicity Cricetinae Female Mesocricetus Mice Mice, Inbred BALB C Vaccination Virulence Factors/metabolism
Chemicals
Virulence Factors
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Ulrich Ricky L
Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702-5011, USA.
DeShazer David
References (9)
9 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/IAI.72.2.1150-1154.2004
Published
2004-02-00
Pages
1150-4
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC321613
Subset
IM
External Links
PubMed source DOI: 10.1128/IAI.72.2.1150-1154.2004 PMC Full Text View journal details
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