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PMID: 14748924 Published · epublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Association studies for asthma and atopic diseases: a comprehensive review of the literature.

Respiratory research ·Vol. 4 ·2003-00-00 ·Pages 14

Hoffjan S, Nicolae D, Ober C

Abstract

Hundreds of genetic association studies on asthma-related phenotypes have been conducted in different populations. To date, variants in 64 genes have been reported to be associated with asthma or related traits in at least one study. Of these, 33 associations were replicated in a second study, 9 associations were not replicated either in a second study or a second sample in the same study, and 22 associations were reported in just a single published study. These results suggest the potential for a great amount of heterogeneity underlying asthma. However, many of these studies are methodologically limited and their interpretation hampered by small sample sizes.

MeSH Terms
Asthma/genetics Genetic Variation Humans Hypersensitivity/genetics Phenotype
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Hoffjan Sabine
Department of Human Genetics, The University of Chicago, Chicago, IL 60637, USA.
Nicolae Dan
Ober Carole
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Article Info
Journal
Respiratory research
Abbr.
Respir Res
ISSN
1465-993X
DOI
10.1186/1465-9921-4-14
Published
2003-00-00
Epub
2003-00-04
Pages
14
Language
English
Region
England
NLM ID
101090633
PMCID
PMC314398
Subset
IM
Grants
NHLBI NIH HHS · HL56399 · United States
NHLBI NIH HHS · R01 HL066533 · United States
NHLBI NIH HHS · HL72414 · United States
NHLBI NIH HHS · HL70831 · United States
NHLBI NIH HHS · R01 HL072414 · United States
NHLBI NIH HHS · P01 HL070831 · United States
NHLBI NIH HHS · P50 HL056399 · United States
NHLBI NIH HHS · HL66533 · United States
External Links
PubMed source DOI: 10.1186/1465-9921-4-14 PMC Full Text View journal details
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