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PMID: 14872096 Published · epublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S.

Local excitation, global inhibition mechanism for gradient sensing: an interactive applet.

Science's STKE : signal transduction knowledge environment ·Vol. 2004 ·No. 219 ·2004-02-03 ·Pages pl3

Kutscher B, Devreotes P, Iglesias PA

Abstract

We have proposed a model in which cells detect gradients of chemoattractant by balancing a fast local excitation and a slower global inhibition. To illustrate this general mechanism, we have developed an interactive applet that mimics laboratory experiments in which either spatially homogeneous or heterogeneous stimuli of chemoattractant are applied.

MeSH Terms

Actins/antagonists & inhibitors,physiology Cell Movement/physiology Chemotactic Factors/physiology Chemotaxis/physiology Computer Simulation/trends Cytoskeleton/metabolism,physiology Enzyme Inhibitors/metabolism Internet Models, Biological Programming Languages Signal Transduction/physiology Software User-Computer Interface

Chemicals

Actins Chemotactic Factors Enzyme Inhibitors

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Kutscher Brett

Department of Electrical and Computer Engineering, Johns Hopkins University, 3400 North Charles Street, 226 Barton Hall, Baltimore, MD 21218, USA.

Devreotes Peter

Iglesias Pablo A

Article Info

Journal

Science's STKE : signal transduction knowledge environment

Abbr.

Sci STKE

ISSN

1525-8882

DOI

10.1126/stke.2192004pl3

Published

2004-02-03

Epub

2004-00-03

Pages

pl3

Language

English

Region

United States

NLM ID

100964423

Subset

External Links

PubMed source DOI: 10.1126/stke.2192004pl3

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