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PMID: 1495974 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

pokkuri, a Drosophila gene encoding an E-26-specific (Ets) domain protein, prevents overproduction of the R7 photoreceptor.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 89 ·No. 15 ·1992-08-01 ·Pages 6856-60

Tei H, Nihonmatsu I, Yokokura T, Ueda R, Sano Y, Okuda T, Sato K, Hirata K, Fujita SC, Yamamoto D

Abstract

Studies on sevenless and bride of sevenless genes have revealed that the R8 cell plays a key role in the fate of the R7 photoreceptor cell, presenting on its surface an inductive cue to which R7 responds. sev-independent induction of R7 cells has been reported in the seven-up mutation, which appears to transform R1 and R6 cells to R7 cells. We have induced recessive mutations in a gene pokkuri (pok; pokkuri is a Japanese word that means "dropping dead") that lead to overproduction of R7 cells with rather minor effects on outer photoreceptors and R8 cells. Pok protein may function as a transcription factor, as the predicted amino acid sequence contains a region similar to the consensus established for the E-26-specific (Ets) domain.

MeSH Terms

Amino Acid Sequence Animals Base Sequence Crosses, Genetic DNA-Binding Proteins Drosophila/genetics,physiology Eye Proteins/genetics Female Genes Genetic Carrier Screening Genotype Homozygote Humans Male Molecular Sequence Data Mosaicism Photoreceptor Cells/cytology,physiology Protein-Tyrosine Kinases/genetics Proto-Oncogene Protein c-ets-2 Proto-Oncogene Proteins/genetics Proto-Oncogene Proteins c-ets Proto-Oncogenes Repressor Proteins Restriction Mapping Sequence Homology, Nucleic Acid Trans-Activators Transcription Factors

Chemicals

DNA-Binding Proteins ERF protein, human ETS2 protein, human Eye Proteins Proto-Oncogene Protein c-ets-2 Proto-Oncogene Proteins Proto-Oncogene Proteins c-ets Repressor Proteins Trans-Activators Transcription Factors Protein-Tyrosine Kinases

Authors & Affiliations

10 authors, click to expand affiliations / ORCID

Tei H

Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan.

Nihonmatsu I

Yokokura T

Ueda R

Sano Y

Okuda T

Sato K

Hirata K

Fujita S C

Yamamoto D

References (13)

13 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.89.15.6856

Published

1992-08-01

Pages

6856-60

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC49603

Subset

Databases

GENBANK

D10228

External Links

PubMed source DOI: 10.1073/pnas.89.15.6856 PMC Full Text View journal details

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pokkuri, a Drosophila gene encoding an E-26-specific (Ets) domain protein, prevents overproduction of the R7 photoreceptor.

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