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PMID: 14971646 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

Molecular mechanisms of arsenic carcinogenesis.

Molecular and cellular biochemistry ·Vol. 255 ·No. 1-2 ·2004-01-00 ·Pages 57-66

Huang C, Ke Q, Costa M, Shi X

Abstract

Arsenic is a metalloid compound that is widely distributed in the environment. Human exposure of this compound has been associated with increased cancer incidence. Although the exact mechanisms remain to be investigated, numerous carcinogenic pathways have been proposed. Potential carcinogenic actions for arsenic include oxidative stress, genotoxic damage, DNA repair inhibition, epigenetic events, and activation of certain signal transduction pathways leading to abberrant gene expression. In this article, we summarize current knowledge on the molecular mechanisms of arsenic carcinogenesis with an emphasis on ROS and signal transduction pathways.

MeSH Terms
Animals Arsenic/metabolism,toxicity Cell Transformation, Neoplastic/chemically induced Cricetinae Cytokines/metabolism DNA Damage/physiology DNA Repair/physiology Environmental Pollutants/adverse effects Gene Expression Regulation, Neoplastic/drug effects Humans Mice Mutagens/metabolism Oncogenes/physiology Oxidative Stress/physiology Protein Kinases/metabolism Rabbits Rats Reactive Oxygen Species/metabolism Signal Transduction/drug effects Transcription Factors/metabolism
Chemicals
Cytokines Environmental Pollutants Mutagens Reactive Oxygen Species Transcription Factors Protein Kinases Arsenic
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Huang Chuanshu
Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, NY 10987, USA. [email protected]
Ke Qingdong
Costa Max
Shi Xianglin
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Article Info
Journal
Molecular and cellular biochemistry
Abbr.
Mol Cell Biochem
ISSN
0300-8177
DOI
10.1023/b:mcbi.0000007261.04684.78
Email
[email protected]
Published
2004-01-00
Pages
57-66
Language
English
Region
Netherlands
NLM ID
0364456
Subset
IM
Grants
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