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PMID: 15001781 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

A toll-like receptor that prevents infection by uropathogenic bacteria.

Science (New York, N.Y.) ·Vol. 303 ·No. 5663 ·2004-03-05 ·Pages 1522-6

Zhang D, Zhang G, Hayden MS, Greenblatt MB, Bussey C, Flavell RA, Ghosh S

Abstract

Toll-like receptors (TLRs) recognize molecular patterns displayed by microorganisms, and their subsequent activation leads to the transcription of appropriate host-defense genes. Here we report the cloning and characterization of a member of the mammalian TLR family, TLR11, that displays a distinct pattern of expression in macrophages and liver, kidney, and bladder epithelial cells. Cells expressing TLR11 fail to respond to known TLR ligands but instead respond specifically to uropathogenic bacteria. Mice lacking TLR11 are highly susceptible to infection of the kidneys by uropathogenic bacteria, indicating a potentially important role for TLR11 in preventing infection of internal organs of the urogenital system.

MeSH Terms

Amino Acid Sequence Animals Cell Line Cloning, Molecular Codon, Terminator Colony Count, Microbial Disease Susceptibility Epithelial Cells/metabolism Escherichia coli/growth & development,immunology,pathogenicity Escherichia coli Infections/immunology,microbiology Gene Expression Profiling Humans Immunity, Innate Kidney/immunology,metabolism,microbiology Ligands Liver/metabolism Macrophages/metabolism Mice Mice, Knockout Molecular Sequence Data NF-kappa B/metabolism Polymorphism, Genetic Receptors, Cell Surface/chemistry,genetics,metabolism Recombinant Fusion Proteins/metabolism Signal Transduction Toll-Like Receptors Transfection Tumor Necrosis Factor-alpha/metabolism Urinary Bladder/immunology,metabolism,microbiology Urinary Tract Infections/immunology,microbiology

Chemicals

Codon, Terminator Ligands NF-kappa B Receptors, Cell Surface Recombinant Fusion Proteins TLR11 protein, human Tlr11 protein, mouse Toll-Like Receptors Tumor Necrosis Factor-alpha

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Zhang Dekai

Section of Immunobiology and Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA.

Zhang Guolong

Hayden Matthew S

Greenblatt Matthew B

Bussey Crystal

Flavell Richard A

Ghosh Sankar

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

1095-9203

DOI

10.1126/science.1094351

Published

2004-03-05

Pages

1522-6

Language

English

Region

United States

NLM ID

0404511

Subset

Grants

NIGMS NIH HHS · GM07205 · United States

NIAID NIH HHS · R01-AI59440 · United States

NIAID NIH HHS · R37-AI33443 · United States

Corrections

CommentIn

PMID: 15001768

External Links

PubMed source DOI: 10.1126/science.1094351 View journal details

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A toll-like receptor that prevents infection by uropathogenic bacteria.

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