Home LiteratureArticle Details

PMID: 15046607 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Physiological functions of protein kinase B/Akt.

Biochemical Society transactions ·Vol. 32 ·No. Pt 2 ·2004-04-00 ·Pages 350-4

Yang ZZ, Tschopp O, Baudry A, Dümmler B, Hynx D, Hemmings BA

Abstract

The genetic manipulation of mice has become an essential and elegant method for studying the function of proteins in physiology, and for testing the veracity of information obtained from cell culture experiments. During the past few years, a variety of transgenic and knockout mouse models of PKB (protein kinase B)/Akt have been generated and investigated. In this paper, we focus on the phenotypes of these PKB/Akt overexpression and mutant mice that may help to elucidate the functions exerted by PKB/Akt in mammals.

MeSH Terms

Animals Brain/pathology Diabetes Mellitus/pathology Disease Models, Animal Female Humans Lymphoma/pathology Male Mammary Glands, Animal/metabolism Mice Mice, Knockout Mice, Transgenic Milk/metabolism Mutation Myocardium/metabolism Phenotype Prostatic Neoplasms/metabolism Protein Serine-Threonine Kinases/genetics,physiology Proto-Oncogene Proteins/genetics,physiology Proto-Oncogene Proteins c-akt Thymus Neoplasms/pathology

Chemicals

Proto-Oncogene Proteins AKT1 protein, human Protein Serine-Threonine Kinases Proto-Oncogene Proteins c-akt

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Yang Z-Z

Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland.

Tschopp O

Baudry A

Dümmler B

Hynx D

Hemmings B A

Article Info

Journal

Biochemical Society transactions

Abbr.

Biochem Soc Trans

ISSN

0300-5127

DOI

10.1042/bst0320350

Published

2004-04-00

Pages

350-4

Language

English

Region

England

NLM ID

7506897

Subset

External Links

PubMed source DOI: 10.1042/bst0320350 View journal details

Analysis Services

Physiological functions of protein kinase B/Akt.

Contact

WeChat Official Account