Negative control of photoreceptor development in Drosophila by the product of the yan gene, an ETS domain protein.

Cell ·Vol. 70 ·No. 4 ·1992-08-21 ·Pages 609-20

Lai ZC, Rubin GM

Abstract

Loss-of-function mutations in the yan gene result in the differentiation of supernumerary photoreceptors in the Drosophila eye. The yan gene encodes a protein with an ETS DNA-binding domain that accumulates in the nuclei of undifferentiated cells during the early stages of eye development. Our data suggest that yan functions as a cell-autonomous negative regulator of photoreceptor development; in the presumptive R7 and cone cells, yan appears to act antagonistically to the proneural signal mediated by sevenless and Ras1.

Related Genes

yan

MeSH Terms

Amino Acid Sequence Animals Base Sequence DNA-Binding Proteins/genetics,isolation & purification Drosophila/embryology,genetics Drosophila Proteins Eye Proteins/genetics,isolation & purification Gene Expression Regulation Molecular Sequence Data Morphogenesis Mutation Photoreceptor Cells/embryology Repressor Proteins Sequence Alignment Transcription Factors/genetics

Chemicals

AOP protein, Drosophila DNA-Binding Proteins Drosophila Proteins Eye Proteins Repressor Proteins Transcription Factors

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Lai Z C

Howard Hughes Medical Institute, University of California, Berkeley 94720.

Rubin G M

Article Info

Journal

Cell

Abbr.

Cell

ISSN

0092-8674

DOI

10.1016/0092-8674(92)90430-k

Published

1992-08-21

Pages

609-20

Language

English

Region

United States

NLM ID

0413066

Subset

Databases

GENBANK

L05499, M87278, M94264, M97693, M97694, S72766, S72767, S72768, S72769, S72771

External Links

PubMed source DOI: 10.1016/0092-8674(92)90430-k View journal details

Analysis Services

Negative control of photoreceptor development in Drosophila by the product of the yan gene, an ETS domain protein.

Contact

WeChat Official Account