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PMID: 15067307 Published · ppublish English Journal Article Review

Multiple sclerosis.

The Journal of clinical investigation ·Vol. 113 ·No. 6 ·2004-03-00 ·Pages 788-94

Hafler DA

Abstract

Multiple sclerosis is a complex genetic disease associated with inflammation in the CNS white matter thought to be mediated by autoreactive T cells. Clonal expansion of B cells, their antibody products, and T cells, hallmarks of inflammation in the CNS, are found in MS. This review discusses new methods to define the molecular pathology of human disease with high-throughput examination of germline DNA haplotypes, RNA expression, and protein structures that will allow the generation of a new series of hypotheses that can be tested to develop better understanding of and therapies for this disease.

MeSH Terms
Humans Multiple Sclerosis/diagnosis,drug therapy,pathology,physiopathology
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Hafler David A
Laboratory of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. [email protected]
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Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/JCI21357
Email
[email protected]
Published
2004-03-00
Pages
788-94
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC362131
Subset
IM
External Links
PubMed source DOI: 10.1172/JCI21357 PMC Full Text View journal details
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