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PMID: 1508183 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Evidence for a role of protein kinase C zeta subspecies in maturation of Xenopus laevis oocytes.

Molecular and cellular biology ·Vol. 12 ·No. 9 ·1992-09-00 ·Pages 3776-83

Dominguez I, Diaz-Meco MT, Municio MM, Berra E, García de Herreros A, Cornet ME, Sanz L, Moscat J

Abstract

A number of studies have demonstrated the activation of phospholipase C-mediated hydrolysis of phosphatidylcholine (PC-PLC) both by growth factors and by the product of the ras oncogene, p21ras. Evidence has been presented indicating that the stimulation of this phospholipid degradative pathway is sufficient to activate mitogenesis in fibroblasts as well as that it is sufficient and necessary for induction of maturation in Xenopus laevis oocytes. However, the mechanism whereby PC-PLC transduces mitogenic signals triggered by growth factors or oncogenes remains to be elucidated. In this study, data are presented that show the involvement of protein kinase C zeta subspecies in the channelling of the mitogenic signal activated by insulin-p21ras-PC-PLC in Xenopus oocytes as well as the lack of a critical role of protein kinase C isotypes alpha, beta, gamma, delta, and epsilon in these pathways.

MeSH Terms
Amino Acid Sequence Animals Base Sequence Cells, Cultured DNA Immunoblotting Maturation-Promoting Factor/physiology Molecular Sequence Data Oocytes/cytology,enzymology Oogenesis/physiology Protein Kinase C/antagonists & inhibitors,genetics,physiology RNA, Antisense/pharmacology Signal Transduction Tetradecanoylphorbol Acetate/pharmacology Xenopus laevis
Chemicals
RNA, Antisense DNA Protein Kinase C Maturation-Promoting Factor Tetradecanoylphorbol Acetate
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Dominguez I
Centro de Biología Molecular, CSIC-UAM, Madrid, Spain.
Diaz-Meco M T
Municio M M
Berra E
García de Herreros A
Cornet M E
Sanz L
Moscat J
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32 references, click to expand
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Article Info
Journal
Molecular and cellular biology
Abbr.
Mol Cell Biol
ISSN
0270-7306
DOI
10.1128/mcb.12.9.3776-3783.1992
Published
1992-09-00
Pages
3776-83
Language
English
Region
United States
NLM ID
8109087
PMCID
PMC360243
Subset
IM
External Links
PubMed source DOI: 10.1128/mcb.12.9.3776-3783.1992 PMC Full Text View journal details
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