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PMID: 15102907 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Inferior temporal, prefrontal, and hippocampal contributions to visual working memory maintenance and associative memory retrieval.

The Journal of neuroscience : the official journal of the Society for Neuroscience ·Vol. 24 ·No. 16 ·2004-04-21 ·Pages 3917-25

Ranganath C, Cohen MX, Dam C, D'Esposito M

Abstract

Higher order cognition depends on the ability to recall information from memory and hold it in mind to guide future behavior. To specify the neural mechanisms underlying these processes, we used event-related functional magnetic resonance imaging to compare brain activity during the performance of a visual associative memory task and a visual working memory task. Activity within category-selective subregions of inferior temporal cortex reflected the type of information that was actively maintained during both the associative memory and working memory tasks. In addition, activity in the anterior prefrontal cortex and hippocampus was specifically enhanced during associative memory retrieval. These data are consistent with the view that the active maintenance of visual information is supported by activation of object representations in inferior temporal cortex, but that goal-directed associative memory retrieval additionally depends on top-down signals from the anterior prefrontal cortex and medial temporal lobes.

MeSH Terms
Adolescent Adult Association Brain Mapping Female Hippocampus/anatomy & histology,physiology Humans Magnetic Resonance Imaging Male Memory/physiology Memory, Short-Term/physiology Mental Recall/physiology Pattern Recognition, Visual/physiology Photic Stimulation/methods Prefrontal Cortex/anatomy & histology,physiology Reference Values Temporal Lobe/anatomy & histology,physiology
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Ranganath Charan
Center for Neuroscience and Department of Psychology, University of California at Davis, Davis, California 95616, USA. [email protected]
Cohen Michael X
Dam Cathrine
D'Esposito Mark
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Article Info
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
Abbr.
J Neurosci
ISSN
1529-2401
DOI
10.1523/JNEUROSCI.5053-03.2004
Email
[email protected]
Published
2004-04-21
Pages
3917-25
Language
English
Region
United States
NLM ID
8102140
PMCID
PMC6729418
Subset
IM
Grants
NIA NIH HHS · AG09253 · United States
NIA NIH HHS · R01 AG015793 · United States
NIA NIH HHS · R01 AG009253 · United States
NIA NIH HHS · AG15793 · United States
NINDS NIH HHS · NS40813 · United States
NIA NIH HHS · AG05863 · United States
NIA NIH HHS · R37 AG009253 · United States
NIA NIH HHS · F32 AG005863 · United States
NIMH NIH HHS · MH63901 · United States
NINDS NIH HHS · P01 NS040813 · United States
NIMH NIH HHS · R01 MH063901 · United States
NCI NIH HHS · P01 CA095616 · United States
External Links
PubMed source DOI: 10.1523/JNEUROSCI.5053-03.2004 PMC Full Text View journal details
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