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PMID: 15105281 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Cardiovascular biology of the asymmetric dimethylarginine:dimethylarginine dimethylaminohydrolase pathway.

Arteriosclerosis, thrombosis, and vascular biology ·Vol. 24 ·No. 6 ·2004-06-00 ·Pages 1023-30

Vallance P, Leiper J

Abstract

An increasing number of reports indicate that endogenously produced inhibitors of nitric oxide synthase, particularly asymmetric dimethylarginine (ADMA), regulate nitric oxide generation in disease states. This article describes the biology of ADMA and the implications for cardiovascular physiology and pathophysiology.

MeSH Terms
Amidohydrolases/antagonists & inhibitors,metabolism Animals Arginine/analogs & derivatives,metabolism Cardiovascular Diseases/drug therapy,metabolism,physiopathology Cardiovascular Physiological Phenomena Diabetes Mellitus/metabolism Endothelium, Vascular/metabolism,physiopathology Enzyme Inhibitors/therapeutic use Female Humans Mice Models, Biological Nitric Oxide/metabolism Nitric Oxide Synthase/antagonists & inhibitors Pre-Eclampsia/metabolism Pregnancy Protein-Arginine N-Methyltransferases/metabolism Renal Insufficiency/metabolism omega-N-Methylarginine/pharmacology
Chemicals
Enzyme Inhibitors omega-N-Methylarginine Nitric Oxide N,N-dimethylarginine Arginine Nitric Oxide Synthase Protein-Arginine N-Methyltransferases Amidohydrolases dimethylargininase
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Vallance Patrick
BHF Laboratories, Division of Medicine, University College London, Rayne Institute, 5 University St, London WC1 6JJ, UK. [email protected]
Leiper James
Article Info
Journal
Arteriosclerosis, thrombosis, and vascular biology
Abbr.
Arterioscler Thromb Vasc Biol
ISSN
1524-4636
Published
2004-06-00
Epub
2004-00-22
Pages
1023-30
Language
English
Region
United States
NLM ID
9505803
Subset
IM
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