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PMID: 1510675 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Genes for bone morphogenetic proteins are differentially transcribed in early amphibian embryos.

Biochemical and biophysical research communications ·Vol. 186 ·No. 3 ·1992-08-14 ·Pages 1487-95

Nishimatsu S, Suzuki A, Shoda A, Murakami K, Ueno N

Abstract

We have previously demonstrated that activin, a member of the TGF-beta family, has a potent mesoderm-inducing activity in Xenopus embryos. In the course of screening for activin-related genes from Xenopus, we have cloned cDNAs for Xenopus homologue of BMP-2, -4 and -7. Northern blot analysis revealed that these BMP genes are maternally encoded and differentially regulated after fertilization. Alkaline phosphatase-inducing assay using the recombinant BMP proteins has shown that at least BMP-2 and -4 have similar activity to mammalian counterparts.

MeSH Terms
Alkaline Phosphatase/pharmacology Amino Acid Sequence Animals Blotting, Northern Bone Morphogenetic Proteins Cell Line DNA/genetics,isolation & purification Embryo, Nonmammalian/physiology Gene Expression Regulation Growth Substances/genetics Molecular Sequence Data Proteins/genetics,pharmacology RNA, Messenger/genetics,isolation & purification Recombinant Proteins/pharmacology Restriction Mapping Sequence Homology, Nucleic Acid Software Transcription, Genetic Transfection Xenopus/embryology
Chemicals
Bone Morphogenetic Proteins Growth Substances Proteins RNA, Messenger Recombinant Proteins DNA Alkaline Phosphatase
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Nishimatsu S
Institute of Applied Biochemistry, University of Tsukuba, Ibaraki, Japan.
Suzuki A
Shoda A
Murakami K
Ueno N
Article Info
Journal
Biochemical and biophysical research communications
Abbr.
Biochem Biophys Res Commun
ISSN
0006-291X
DOI
10.1016/s0006-291x(05)81574-8
Published
1992-08-14
Pages
1487-95
Language
English
Region
United States
NLM ID
0372516
Subset
IM
Databases
GENBANK
D10916, D10917, D10918, D10919, D10920, S39221, X63424, X63425, X63426, X63427
External Links
PubMed source DOI: 10.1016/s0006-291x(05)81574-8 View journal details
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