Bcl-2: a repressor of lymphocyte death.

Immunology today ·Vol. 13 ·No. 8 ·1992-08-00 ·Pages 285-8

Korsmeyer SJ

Abstract

The genes and mechanisms that control programmed cell death are currently the subject of intense study. The bcl-2 gene, a repressor of lymphocyte death, is perhaps the best understood of the programmed cell death associated genes. Here, Stanley Korsmeyer provides a brief overview of bcl-2, concentrating on its roles in B- and T-cell development and in oncogenesis.

Related Genes

bcl-2

MeSH Terms

Animals B-Lymphocytes Cell Death/genetics GTP-Binding Proteins/genetics Humans Lymphocyte Activation Lymphoma/genetics,immunology Mice Mice, Transgenic Proto-Oncogene Proteins/genetics Proto-Oncogene Proteins c-bcl-2 Repressor Proteins/genetics T-Lymphocytes

Chemicals

Proto-Oncogene Proteins Proto-Oncogene Proteins c-bcl-2 Repressor Proteins GTP-Binding Proteins

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Korsmeyer S J

Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, MO 63110.

Article Info

Journal

Immunology today

Abbr.

Immunol Today

ISSN

0167-5699

DOI

10.1016/0167-5699(92)90037-8

Published

1992-08-00

Pages

285-8

Language

English

Region

England

NLM ID

8008346

Subset

External Links

PubMed source DOI: 10.1016/0167-5699(92)90037-8

Analysis Services

Bcl-2: a repressor of lymphocyte death.

Contact

WeChat Official Account