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PMID: 1511495 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Tumor cell adhesion to the extracellular matrix and signal transduction mechanisms implicated in tumor cell motility, invasion and metastasis.

Cancer metastasis reviews ·Vol. 11 ·No. 1 ·1992-03-00 ·Pages 31-44

Lester BR, McCarthy JB

Abstract

The relationship between tumor cell adhesion to the extracellular matrix (ECM) and invasion and metastasis formation is one of the most intensively studied topics in cancer biology within the last 10-15 years. The aberrant molecular relationships between malignant tumor cells and their surrounding ECM have been implicated at virtually every stage of the metastatic process; ranging from steps that involve the local invasion of tumor cells away from the primary tumor to those that are involved in mediating extravasation through microvessel-associated basement membranes at the site(s) of metastasis formation. The complexity of tumor metastasis has required that a reductionist approach be taken in order to identify and relate specific molecular mechanisms involved in tumor cell adhesion to various aspects of tumor metastasis. The intensive research efforts into cell adhesion and tumor cell biology have generated many significant new concepts towards our understanding of the molecular aspects of tumor cell adhesion and metastasis. Our purpose in this article is to briefly summarize the relationship of ECM-stimulated tumor cell adhesion to the processes of tumor cell motility and invasion. This is followed by a discussion of certain aspects of signal transduction pathways that may impact on cell motility, with an emphasis on the relationship between phosphatidylinositol hydrolysis and actin polymerization, as well as certain GTP-binding protein-(G-protein) mediated events that could influence cytoskeletal organization and cell motility. Our emphasis is based on increasing evidence that implicates members of the signal transduction G-proteins in the motility and invasion of many normal and transformed cells.

MeSH Terms
Actins/physiology Animals Cell Adhesion/physiology Cell Movement Extracellular Matrix/physiology GTP-Binding Proteins/physiology Humans Mice Neoplasm Invasiveness/physiopathology Neoplasm Metastasis/physiopathology Neoplasms/pathology Phosphatidylinositols/metabolism Signal Transduction/physiology
Chemicals
Actins Phosphatidylinositols GTP-Binding Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Lester B R
University of Minnesota, Department of Laboratory Medicine and Pathology, Minneapolis.
McCarthy J B
References (97)
97 references, click to expand
  1. Inhibition of lymphocyte and neutrophil chemotaxis by pertussis toxin.
    J Immunol. 1985 Dec;135(6):4135-43 PMID: 2999238
  2. Mechanisms of action of calcium-mobilizing agonists: some variations on a young theme.
    FASEB J. 1988 Aug;2(11):2670-6 PMID: 2456243
  3. Biochemical regulation of adenylate cyclase in murine melanoma clones with different metastatic properties.
    Int J Cancer. 1986 May 15;37(5):713-22 PMID: 3009332
  4. Inositol trisphosphate and diacylglycerol: two interacting second messengers.
    Annu Rev Biochem. 1987;56:159-93 PMID: 3304132
  5. The implications of tumor heterogeneity for studies on the biology of cancer metastasis.
    Biochim Biophys Acta. 1981 Aug 31;651(1):37-50 PMID: 7025905
  6. Adhesion and cytoskeletal organisation of fibroblasts in response to fibronectin fragments.
    EMBO J. 1986 Apr;5(4):665-70 PMID: 3709521
  7. Evidence that the phosphatidylinositol cycle is linked to cell motility.
    Exp Cell Res. 1988 Jan;174(1):1-15 PMID: 2826193
  8. Stimulation of phospholipase A2 activity in bovine rod outer segments by the beta gamma subunits of transducin and its inhibition by the alpha subunit.
    Proc Natl Acad Sci U S A. 1987 Jun;84(11):3623-7 PMID: 3108876
  9. Cell surface proteoglycan associates with the cytoskeleton at the basolateral cell surface of mouse mammary epithelial cells.
    J Cell Biol. 1986 Dec;103(6 Pt 2):2683-96 PMID: 3025223
  10. The sensation and regulation of interactions with the extracellular environment: the cell biology of lymphocyte adhesion receptors.
    Annu Rev Cell Biol. 1990;6:359-402 PMID: 2275817
  11. Determination of platelet adhesion to collagen and the associated formation of phosphatidic acid and calcium mobilization.
    Anal Biochem. 1990 May 15;187(1):173-8 PMID: 2372114
  12. The molecular basis and specificity of integrin-ligand interactions.
    J Cell Sci. 1990 Dec;97 ( Pt 4):585-92 PMID: 2077034
  13. Binding of hyaluronic acid to lymphoid cell lines is inhibited by monoclonal antibodies against Pgp-1.
    Exp Cell Res. 1990 Apr;187(2):224-33 PMID: 2180732
  14. Integrins.
    J Clin Invest. 1991 Jan;87(1):1-5 PMID: 1985087
  15. Morphoregulatory molecules.
    Biochemistry. 1988 May 17;27(10):3533-43 PMID: 3044445
  16. The beta gamma subunits of GTP-binding proteins activate the muscarinic K+ channel in heart.
    Nature. 1987 Jan 22-28;325(6102):321-6 PMID: 2433589
  17. Phospholipase A2 and phospholipase C are activated by distinct GTP-binding proteins in response to alpha 1-adrenergic stimulation in FRTL5 thyroid cells.
    Proc Natl Acad Sci U S A. 1986 Oct;83(19):7201-5 PMID: 3020540
  18. Simultaneous inhibitions of inositol phospholipid breakdown, arachidonic acid release, and histamine secretion in mast cells by islet-activating protein, pertussis toxin. A possible involvement of the toxin-specific substrate in the Ca2+-mobilizing receptor-mediated biosignaling system.
    J Biol Chem. 1985 Mar 25;260(6):3584-93 PMID: 2579078
  19. ADP-ribosylation of the specific membrane protein by islet-activating protein, pertussis toxin, associated with inhibition of a chemotactic peptide-induced arachidonate release in neutrophils. A possible role of the toxin substrate in Ca2+-mobilizing biosignaling.
    J Biol Chem. 1984 Nov 25;259(22):13863-71 PMID: 6209272
  20. Autocrine motility factor stimulates a three-fold increase in inositol trisphosphate in human melanoma cells.
    Biochem Biophys Res Commun. 1990 Jan 30;166(2):757-64 PMID: 2154219
  21. G proteins: a family of signal transducers.
    Annu Rev Cell Biol. 1986;2:391-419 PMID: 3103658
  22. The role of G-protein in matrix-mediated motility of highly and poorly invasive melanoma cells.
    Int J Cancer. 1991 Apr 22;48(1):113-20 PMID: 1850381
  23. Localization and chemical synthesis of fibronectin peptides with melanoma adhesion and heparin binding activities.
    Biochemistry. 1988 Feb 23;27(4):1380-8 PMID: 2966638
  24. Role of collagenous matrices in the adhesion and growth of cells.
    J Cell Biol. 1981 Mar;88(3):473-85 PMID: 7012158
  25. Pertussis toxin inhibition of chemotactic factor-induced calcium mobilization and function in human polymorphonuclear leukocytes.
    J Exp Med. 1985 Jul 1;162(1):145-56 PMID: 2989409
  26. A cell surface chondroitin sulfate proteoglycan, immunologically related to CD44, is involved in type I collagen-mediated melanoma cell motility and invasion.
    J Cell Biol. 1992 Jan;116(2):521-31 PMID: 1730766
  27. The subunits of the stimulatory regulatory component of adenylate cyclase. Resolution of the activated 45,000-dalton (alpha) subunit.
    J Biol Chem. 1983 Sep 25;258(18):11369-76 PMID: 6309844
  28. Regions of the alpha 1-adrenergic receptor involved in coupling to phosphatidylinositol hydrolysis and enhanced sensitivity of biological function.
    Proc Natl Acad Sci U S A. 1990 Apr;87(8):2896-900 PMID: 2158097
  29. Mechanism of the interaction of human platelet profilin with actin.
    J Cell Biol. 1991 Jun;113(5):1081-9 PMID: 1645736
  30. Involvement of GTP-binding proteins in actin polymerization in human neutrophils.
    Proc Natl Acad Sci U S A. 1990 Apr;87(8):2921-5 PMID: 2109319
  31. Light activation of phospholipase A2 in rod outer segments of bovine retina and its modulation by GTP-binding proteins.
    J Biol Chem. 1987 Jan 5;262(1):163-8 PMID: 3025201
  32. Inhibition of lymphoma invasion and liver metastasis formation by pertussis toxin.
    Cancer Res. 1987 Oct 15;47(20):5439-44 PMID: 3652046
  33. The role of hormone receptors and GTP-regulatory proteins in membrane transduction.
    Nature. 1980 Mar 6;284(5751):17-22 PMID: 6101906
  34. Cell adhesion receptor expression during melanoma progression and metastasis.
    Cancer Metastasis Rev. 1991 Jun;10(2):115-28 PMID: 1873852
  35. Role of guanine nucleotide binding protein in the activation of polyphosphoinositide phosphodiesterase.
    Nature. 1985 Apr 11-17;314(6011):534-6 PMID: 2986003
  36. Effects of hyaluronate and hyaluronate binding proteins on cell motile and contact behaviour.
    J Cell Sci. 1985 Oct;78:133-45 PMID: 2419350
  37. Association of ligand-receptor complexes with actin filaments in human neutrophils: a possible regulatory role for a G-protein.
    J Cell Biol. 1989 Dec;109(6 Pt 1):2791-9 PMID: 2512299
  38. Regulation of phosphoinositide-specific phospholipase C.
    Biochim Biophys Acta. 1990 Jun 12;1053(1):81-8 PMID: 2163688
  39. Calcium and polyphosphoinositide control of cytoskeletal dynamics.
    Trends Neurosci. 1989 Nov;12(11):468-74 PMID: 2479150
  40. A simple structure encodes G protein-activating function of the IGF-II/mannose 6-phosphate receptor.
    Cell. 1990 Aug 24;62(4):709-17 PMID: 2167177
  41. Roles of G protein subunits in transmembrane signalling.
    Nature. 1988 May 12;333(6169):129-34 PMID: 3130578
  42. Cell-surface glycosaminoglycans.
    Annu Rev Biochem. 1984;53:847-69 PMID: 6433783
  43. Experimental metastasis correlates with cyclic AMP accumulation in B16 melanoma clones.
    Nature. 1984 Apr 5-11;308(5959):544-7 PMID: 6323999
  44. Model systems for the study of seven-transmembrane-segment receptors.
    Annu Rev Biochem. 1991;60:653-88 PMID: 1652922
  45. Membrane-associated 41-kDa GTP-binding protein in collagen-induced platelet activation.
    FASEB J. 1990 Aug;4(11):2925-33 PMID: 2116341
  46. Receptor-phosphoinositidase C coupling. Multiple G-proteins?
    FEBS Lett. 1987 Nov 16;224(1):1-3 PMID: 2824238
  47. Tumor cell instability, diversification, and progression to the metastatic phenotype: from oncogene to oncofetal expression.
    Cancer Res. 1987 Mar 15;47(6):1473-87 PMID: 3545445
  48. Regulation of phospholipase C-gamma 1 by profilin and tyrosine phosphorylation.
    Science. 1991 Mar 8;251(4998):1231-3 PMID: 1848725
  49. The alpha subunit of the GTP binding protein Gk opens atrial potassium channels.
    Science. 1987 Apr 24;236(4800):442-5 PMID: 2436299
  50. Receptor-coupled activation of phosphoinositide-specific phospholipase C by an N protein.
    Science. 1986 Apr 4;232(4746):97-100 PMID: 3006254
  51. Hyaluronan and a cell-associated hyaluronan binding protein regulate the locomotion of ras-transformed cells.
    J Cell Biol. 1991 Mar;112(5):1041-7 PMID: 1705559
  52. GTP-mediated macromolecular interactions: the common features of different systems.
    FASEB J. 1988 May;2(8):2356-67 PMID: 2452111
  53. Identification of a conserved protein motif in a group of growth factor receptors.
    FEBS Lett. 1990 Oct 15;272(1-2):7-11 PMID: 2172020
  54. The extended family of proteoglycans: social residents of the pericellular zone.
    Curr Opin Cell Biol. 1989 Dec;1(6):1201-18 PMID: 2517581
  55. Chemoattractant receptors on phagocytic cells.
    Annu Rev Immunol. 1984;2:257-81 PMID: 6100474
  56. The regulation of actin polymerization in differentiating U937 cells correlates with increased membrane levels of the pertussis-toxin-sensitive G-protein Gi2.
    Biochem J. 1991 May 1;275 ( Pt 3):809-11 PMID: 1645523
  57. Inhibition of receptor-mediated release of arachidonic acid by pertussis toxin.
    Cell. 1984 Dec;39(2 Pt 1):301-8 PMID: 6094010
  58. Reconstitution of the Gs protein from B16 melanoma clones of high and low experimental metastatic potential into S49 cyc-membranes.
    Biochem Biophys Res Commun. 1987 Aug 31;147(1):443-51 PMID: 3115261
  59. Inhibition of chemotactic peptide-induced phosphoinositide hydrolysis by phorbol esters through the activation of protein kinase C in differentiated human leukemia (HL-60) cells.
    Cancer Res. 1986 Jul;46(7):3401-6 PMID: 3011248
  60. Modulating influence of chemotactic factor-induced cell adhesiveness on granulocyte function.
    J Clin Invest. 1979 Jul;64(1):8-16 PMID: 447862
  61. Purification and immunochemical characterization of the major pertussis-toxin-sensitive guanine-nucleotide-binding protein of bovine-neutrophil membranes.
    Eur J Biochem. 1987 May 15;165(1):185-94 PMID: 3106040
  62. Definition of a sequence, RYVVLPR, within laminin peptide F-9 that mediates metastatic fibrosarcoma cell adhesion and spreading.
    Cancer Res. 1990 Dec 1;50(23):7612-22 PMID: 2253210
  63. Two functionally distinct pools of glycosaminoglycan in the substrate adhesion site of murine cells.
    J Cell Biol. 1978 Dec;79(3):788-801 PMID: 569661
  64. Adhesion of glycosaminoglycan-deficient chinese hamster ovary cell mutants to fibronectin substrata.
    J Cell Biol. 1988 Mar;106(3):945-52 PMID: 3346331
  65. Focal adhesions: transmembrane junctions between the extracellular matrix and the cytoskeleton.
    Annu Rev Cell Biol. 1988;4:487-525 PMID: 3058164
  66. G proteins: transducers of receptor-generated signals.
    Annu Rev Biochem. 1987;56:615-49 PMID: 3113327
  67. Human fibronectin contains distinct adhesion- and motility-promoting domains for metastatic melanoma cells.
    J Cell Biol. 1986 Jan;102(1):179-88 PMID: 3941152
  68. Tenascin: an extracellular matrix protein prominent in specialized embryonic tissues and tumors.
    Annu Rev Cell Biol. 1989;5:71-92 PMID: 2480799
  69. Integrins and other cell adhesion molecules.
    FASEB J. 1990 Aug;4(11):2868-80 PMID: 2199285
  70. Signal transduction in cells following binding of chemoattractants to membrane receptors.
    Virchows Arch B Cell Pathol Incl Mol Pathol. 1988;55(2):65-80 PMID: 2901161
  71. Role of phosphoinositides in transmembrane signaling.
    Physiol Rev. 1990 Jan;70(1):115-64 PMID: 2153305
  72. Receptor-effector coupling by G proteins.
    Biochim Biophys Acta. 1990 May 7;1031(2):163-224 PMID: 2160274
  73. CD44 is the principal cell surface receptor for hyaluronate.
    Cell. 1990 Jun 29;61(7):1303-13 PMID: 1694723
  74. A short sequence responsible for both phosphoinositide binding and actin binding activities of cofilin.
    J Biol Chem. 1991 Sep 15;266(26):17218-21 PMID: 1654325
  75. Proteoglycans in cell regulation.
    J Biol Chem. 1989 Aug 15;264(23):13369-72 PMID: 2668264
  76. New perspectives in cell adhesion: RGD and integrins.
    Science. 1987 Oct 23;238(4826):491-7 PMID: 2821619
  77. The role of cell adhesion proteins--laminin and fibronectin--in the movement of malignant and metastatic cells.
    Cancer Metastasis Rev. 1985;4(2):125-52 PMID: 3893683
  78. Inhibition by islet-activating protein of a chemotactic peptide-induced early breakdown of inositol phospholipids and Ca2+ mobilization in guinea pig neutrophils.
    J Biol Chem. 1985 Dec 15;260(29):15771-80 PMID: 2999136
  79. Close and focal contact adhesions of fibroblasts to a fibronectin-containing matrix.
    Fed Proc. 1985 Feb;44(2):394-403 PMID: 3917945
  80. The influence of extracellular matrix on gene expression: is structure the message?
    J Cell Sci Suppl. 1987;8:327-43 PMID: 3332665
  81. Molecular cloning of a phosphatidylinositol-anchored membrane heparan sulfate proteoglycan from human lung fibroblasts.
    J Cell Biol. 1990 Dec;111(6 Pt 2):3165-76 PMID: 2148568
  82. Structure and function of heparan sulphate proteoglycans.
    Biochem J. 1986 Jun 1;236(2):313-25 PMID: 2944511
  83. Evidence for involvement of guanine nucleotide-binding regulatory proteins in the activation of phospholipases by hormones.
    FASEB J. 1988 Jul;2(10 ):2569-74 PMID: 2838362
  84. Type IV collagen-mediated melanoma cell adhesion and migration: involvement of multiple, distinct domains of the collagen molecule.
    Cancer Res. 1989 Sep 1;49(17 ):4796-802 PMID: 2758412
  85. Biochemical interactions of tumor cells with the basement membrane.
    Annu Rev Biochem. 1986;55:1037-57 PMID: 3017189
  86. Adhesion receptors of the immune system.
    Nature. 1990 Aug 2;346(6283):425-34 PMID: 1974032
  87. Extracellular matrices and cell adhesion.
    Arteriosclerosis. 1985 Nov-Dec;5(6):581-94 PMID: 2416306
  88. Tumor invasion and the extracellular matrix.
    Lab Invest. 1983 Dec;49(6):636-49 PMID: 6317982
  89. The GTP-binding protein, Go, regulates neuronal calcium channels.
    Nature. 1987 Jan 29-Feb 4;325(6103):445-7 PMID: 2433590
  90. Tumor cell adhesive mechanisms and their relationship to metastasis.
    Semin Cancer Biol. 1991 Jun;2(3):155-67 PMID: 1912525
  91. Thrombin receptor. Variations on a theme.
    Nature. 1991 May 30;351(6325):353-4 PMID: 1851963
  92. Are guanine nucleotide binding proteins a distinct class of regulatory proteins?
    FEBS Lett. 1983 Nov 28;164(1):1-8 PMID: 6317436
  93. Pertussis toxin inhibits stimulated motility independently of the adenylate cyclase pathway in human melanoma cells.
    Biochem Biophys Res Commun. 1987 Jul 15;146(1):339-45 PMID: 3496885
  94. Enhanced motility in NIH 3T3 fibroblasts that overexpress gelsolin.
    Science. 1991 Mar 8;251(4998):1233-6 PMID: 1848726
  95. The activation dependent adhesion of macrophages to laminin involves cytoskeletal anchoring and phosphorylation of the alpha 6 beta 1 integrin.
    J Cell Biol. 1990 Jun;110(6):2167-74 PMID: 2141029
  96. G-protein involvement in matrix-mediated motility and invasion of high and low experimental metastatic B16 melanoma clones.
    Cancer Res. 1989 Nov 1;49(21):5940-8 PMID: 2477150
  97. How does the extracellular matrix direct gene expression?
    J Theor Biol. 1982 Nov 7;99(1):31-68 PMID: 6892044
Article Info
Journal
Cancer metastasis reviews
Abbr.
Cancer Metastasis Rev
ISSN
0167-7659
DOI
10.1007/BF00047601
Published
1992-03-00
Pages
31-44
Language
English
Region
Netherlands
NLM ID
8605731
Subset
IM
Grants
NCI NIH HHS · CA 43924 · United States
External Links
PubMed source DOI: 10.1007/BF00047601 View journal details
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