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PMID: 15118080 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 101 ·No. 19 ·2004-05-11 ·Pages 7281-6

Iizuka K, Bruick RK, Liang G, Horton JD, Uyeda K

Abstract

The liver provides for long-term energy needs of the body by converting excess carbohydrate into fat for storage. Insulin is one factor that promotes hepatic lipogenesis, but there is increasing evidence that glucose also contributes to the coordinated regulation of carbohydrate and fat metabolism in liver by mechanisms that are independent of insulin. In this study, we show that the transcription factor, carbohydrate response element-binding protein (ChREBP), is required both for basal and carbohydrate-induced expression of several liver enzymes essential for coordinated control of glucose metabolism, fatty acid, and the synthesis of fatty acids and triglycerides in vivo.

MeSH Terms
Animals Base Sequence Basic Helix-Loop-Helix Leucine Zipper Transcription Factors DNA Primers DNA-Binding Proteins/genetics,physiology Glycolysis/physiology Insulin/physiology Male Mice Mice, Inbred C57BL Mice, Knockout Transcription Factors/genetics,physiology
Chemicals
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors DNA Primers DNA-Binding Proteins Insulin Mlxipl protein, rat Transcription Factors
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Iizuka Katsumi
Department of Biochemistry, University of Texas Southwestern Medical Center and Dallas Veterans Affairs Medical Center, 4500 South Lancaster Road, Dallas, TX 75216, USA.
Bruick Richard K
Liang Guosheng
Horton Jay D
Uyeda Kosaku
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18 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.0401516101
Published
2004-05-11
Epub
2004-00-26
Pages
7281-6
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC409910
Subset
IM
Grants
NHLBI NIH HHS · P01 HL020948 · United States
NHLBI NIH HHS · HL 20948 · United States
External Links
PubMed source DOI: 10.1073/pnas.0401516101 PMC Full Text View journal details
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