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PMID: 15118803 Published · ppublish English Journal Article Review

Targeting the dopamine D1 receptor in schizophrenia: insights for cognitive dysfunction.

Psychopharmacology ·Vol. 174 ·No. 1 ·2004-06-00 ·Pages 3-16

Goldman-Rakic PS, Castner SA, Svensson TH, Siever LJ, Williams GV

Abstract

Reinstatement of the function of working memory, the cardinal cognitive process essential for human reasoning and judgment, is potentially the most intractable problem for the treatment of schizophrenia. Since deficits in working memory are associated with dopamine dysregulation and altered D(1) receptor signaling within prefrontal cortex, we present the case for targeting novel drug therapies towards enhancing prefrontal D(1) stimulation for the amelioration of the debilitating cognitive deficits in schizophrenia. This review examines the role of dopamine in regulating cellular and circuit function within prefrontal cortex in order to understand the significance of the dopamine dysregulation found in schizophrenia and related non-human primate models. By revealing the associations among prefrontal neuronal function, dopamine and D(1) signaling, and cognition, we seek to pinpoint the mechanisms by which dopamine modulates working memory processes and how these mechanisms may be exploited to improve cognitive function. Dopamine deficiency within dorsolateral prefrontal cortex leads to abnormal recruitment of this region by cognitive tasks. Both preclinical and clinical studies have demonstrated a direct relationship between prefrontal dopamine function and the integrity of working memory, suggesting that insufficient D(1) receptor signaling in this region results in cognitive deficits. Moreover, working memory deficits can be ameliorated by treatments that augment D(1) receptor stimulation, indicating that this target presents a unique opportunity for the restoration of cognitive function in schizophrenia.

MeSH Terms
Animals Cognition Disorders/etiology,physiopathology Disease Models, Animal Dopamine/metabolism Dopamine Agents/pharmacology Humans Prefrontal Cortex/metabolism,physiopathology Receptors, Dopamine D1/physiology Schizophrenia/complications,metabolism,physiopathology Signal Transduction/physiology
Chemicals
Dopamine Agents Receptors, Dopamine D1 Dopamine
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Goldman-Rakic Patricia S
Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06510, USA.
Castner Stacy A
Svensson Torgny H
Siever Larry J
Williams Graham V
References (190)
190 references, click to expand
  1. A pen-and-paper human analogue of a monkey prefrontal cortex activation task: spatial working memory in patients with schizophrenia.
    Schizophr Res. 1995 Sep;17(1):25-33 PMID: 8541247
  2. Adrogolide HCl (ABT-431; DAS-431), a prodrug of the dopamine D1 receptor agonist, A-86929: preclinical pharmacology and clinical data.
    CNS Drug Rev. 2001 Fall;7(3):305-16 PMID: 11607045
  3. A common action of clozapine, haloperidol, and remoxipride on D1- and D2-dopaminergic receptors in the primate cerebral cortex.
    Proc Natl Acad Sci U S A. 1994 May 10;91(10):4353-6 PMID: 8183912
  4. Decreased prefrontal dopamine D1 receptors in schizophrenia revealed by PET.
    Nature. 1997 Feb 13;385(6617):634-6 PMID: 9024661
  5. Heterogeneous targets of dopamine synapses in monkey prefrontal cortex demonstrated by serial section electron microscopy: a laminar analysis using the silver-enhanced diaminobenzidine sulfide (SEDS) immunolabeling technique.
    Cereb Cortex. 1993 May-Jun;3(3):223-38 PMID: 7686795
  6. Differential modulation by dopamine of responses evoked by excitatory amino acids in human cortex.
    Synapse. 1992 Aug;11(4):330-41 PMID: 1354399
  7. Methylphenidate challenge as a predictor of relapse in schizophrenia.
    Am J Psychiatry. 1984 May;141(5):633-8 PMID: 6143506
  8. Functional MRI of macaque monkeys performing a cognitive set-shifting task.
    Science. 2002 Feb 22;295(5559):1532-6 PMID: 11859197
  9. Neuropsychologic deficits in schizophrenia: relation to social function and effect of antipsychotic drug treatment.
    Neuropsychopharmacology. 1996 Mar;14(3 Suppl):27S-33S PMID: 8866741
  10. Association between Val108/158 Met polymorphism of the COMT gene and schizophrenia.
    Am J Med Genet B Neuropsychiatr Genet. 2003 Jul 1;120B(1):47-50 PMID: 12815739
  11. Working memory dysfunction in schizophrenia.
    J Neuropsychiatry Clin Neurosci. 1994 Fall;6(4):348-57 PMID: 7841806
  12. Cognitive deficits precede motor deficits in a slowly progressing model of parkinsonism in the monkey.
    Neurodegeneration. 1995 Sep;4(3):245-55 PMID: 8581557
  13. Improved short-term spatial memory but impaired reversal learning following the dopamine D(2) agonist bromocriptine in human volunteers.
    Psychopharmacology (Berl). 2001 Dec;159(1):10-20 PMID: 11797064
  14. Neuron-specific age-related decreases in dopamine receptor subtype mRNAs.
    J Comp Neurol. 2003 Feb 3;456(2):176-83 PMID: 12509874
  15. Eye movement disturbances in schizophrenia and a polymorphism of catechol-O-methyltransferase gene.
    Psychiatry Res. 2002 Dec 15;113(1-2):49-57 PMID: 12467945
  16. Primate frontal eye fields. I. Single neurons discharging before saccades.
    J Neurophysiol. 1985 Mar;53(3):603-35 PMID: 3981231
  17. Prefrontal neurons and the genetics of schizophrenia.
    Biol Psychiatry. 2001 Dec 1;50(11):825-44 PMID: 11743939
  18. D1 dopamine receptor activity of anti-parkinsonian drugs.
    Life Sci. 1997;60(18):1597-603 PMID: 9126882
  19. Dopamine enhances EPSCs in layer II-III pyramidal neurons in rat prefrontal cortex.
    J Neurosci. 2003 Feb 1;23(3):867-75 PMID: 12574415
  20. Dopamine innervation of a subclass of local circuit neurons in monkey prefrontal cortex: ultrastructural analysis of tyrosine hydroxylase and parvalbumin immunoreactive structures.
    Cereb Cortex. 1998 Oct-Nov;8(7):614-22 PMID: 9823482
  21. Cognitive impairment in schizophrenia: its impact on social functioning.
    Acta Psychiatr Scand Suppl. 2000;400:11-6 PMID: 10823306
  22. D1 receptor in interneurons of macaque prefrontal cortex: distribution and subcellular localization.
    J Neurosci. 1998 Dec 15;18(24):10553-65 PMID: 9852592
  23. D1 dopamine receptors in prefrontal cortex: involvement in working memory.
    Science. 1991 Feb 22;251(4996):947-50 PMID: 1825731
  24. Excitatory effects of dopamine released by impulse flow in the rat nucleus accumbens in vivo.
    Neuroscience. 1996 Nov;75(1):13-8 PMID: 8923518
  25. Visuospatial working memory in schizotypal personality disorder patients.
    Schizophr Res. 2000 Feb 14;41(3):447-55 PMID: 10728721
  26. The effect of dopamine depletion from the caudate nucleus of the common marmoset (Callithrix jacchus) on tests of prefrontal cognitive function.
    Behav Neurosci. 2000 Feb;114(1):3-17 PMID: 10718258
  27. Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia. II. Role of neuroleptic treatment, attention, and mental effort.
    Arch Gen Psychiatry. 1986 Feb;43(2):126-35 PMID: 2868701
  28. Schizophrenic subjects show aberrant fMRI activation of dorsolateral prefrontal cortex and basal ganglia during working memory performance.
    Biol Psychiatry. 2000 Jul 15;48(2):99-109 PMID: 10903406
  29. Chronic effects of dopaminergic replacement on cognitive function in Parkinson's disease: a two-year follow-up study of previously untreated patients.
    Mov Disord. 2000 Jul;15(4):613-26 PMID: 10928571
  30. Evidence for decreased DARPP-32 in the prefrontal cortex of patients with schizophrenia.
    Arch Gen Psychiatry. 2002 Aug;59(8):705-12 PMID: 12150646
  31. Impact of newer antipsychotics on outcomes in schizophrenia.
    Clin Ther. 1997 Jan-Feb;19(1):148-58; discussion 126-7 PMID: 9083717
  32. Amphetamine response and relapse risk after depot neuroleptic discontinuation.
    Psychopharmacology (Berl). 1985;85(3):277-83 PMID: 2860683
  33. Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia.
    Proc Natl Acad Sci U S A. 2001 Jun 5;98(12):6917-22 PMID: 11381111
  34. Dopamine in schizophrenia: a review and reconceptualization.
    Am J Psychiatry. 1991 Nov;148(11):1474-86 PMID: 1681750
  35. Perseveration and strategy in a novel spatial self-ordered sequencing task for nonhuman primates: effects of excitotoxic lesions and dopamine depletions of the prefrontal cortex.
    J Cogn Neurosci. 1998 May;10(3):332-54 PMID: 9869708
  36. Dopamine D4 receptor antagonist reversal of subchronic phencyclidine-induced object retrieval/detour deficits in monkeys.
    Psychopharmacology (Berl). 1999 Feb;142(1):78-84 PMID: 10102786
  37. The cost of cognitive impairment in schizophrenia.
    Schizophr Res. 1995 Sep;17(1):1-3 PMID: 8541242
  38. Decreased somal size of deep layer 3 pyramidal neurons in the prefrontal cortex of subjects with schizophrenia.
    Arch Gen Psychiatry. 2001 May;58(5):466-73 PMID: 11343526
  39. Effects of dihydrexidine, a full dopamine D-1 receptor agonist, on delayed response performance in chronic low dose MPTP-treated monkeys.
    Brain Res. 1994 Nov 7;663(1):140-4 PMID: 7850462
  40. The effect of amphetamine on regional cerebral blood flow during cognitive activation in schizophrenia.
    J Neurosci. 1991 Jul;11(7):1907-17 PMID: 2066768
  41. Molecular characteristics of mammalian dopamine receptors.
    Pharmacol Toxicol. 1997 Sep;81(3):105-13 PMID: 9335067
  42. Atypical antipsychotics: mechanism of action.
    Can J Psychiatry. 2002 Feb;47(1):27-38 PMID: 11873706
  43. Dopamine transporter-immunoreactive neurons decrease with age in the human substantia nigra.
    J Comp Neurol. 1999 Jun 21;409(1):25-37 PMID: 10363709
  44. Dopaminergic therapy in children with restless legs/periodic limb movements in sleep and ADHD. Dopaminergic Therapy Study Group.
    Pediatr Neurol. 2000 Mar;22(3):182-6 PMID: 10734247
  45. Dopamine D1 receptor mechanisms in the cognitive performance of young adult and aged monkeys.
    Psychopharmacology (Berl). 1994 Oct;116(2):143-51 PMID: 7862943
  46. Characterization of the dopaminergic innervation of the primate frontal cortex using a dopamine-specific antibody.
    Cereb Cortex. 1993 May-Jun;3(3):199-222 PMID: 8100725
  47. Prefrontal dopamine D1 receptors and working memory in schizophrenia.
    J Neurosci. 2002 May 1;22(9):3708-19 PMID: 11978847
  48. Down-regulation of the D1 and D5 dopamine receptors in the primate prefrontal cortex by chronic treatment with antipsychotic drugs.
    J Pharmacol Exp Ther. 1997 Apr;281(1):597-603 PMID: 9103549
  49. Spatial and non-spatial working memory at different stages of Parkinson's disease.
    Neuropsychologia. 1997 Apr;35(4):519-32 PMID: 9106280
  50. The subtype-selective nicotinic acetylcholine receptor agonist SIB-1553A improves both attention and memory components of a spatial working memory task in chronic low dose 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkeys.
    J Pharmacol Exp Ther. 2003 Jul;306(1):401-6 PMID: 12721323
  51. Neurocomputational models of working memory.
    Nat Neurosci. 2000 Nov;3 Suppl:1184-91 PMID: 11127836
  52. An astroglia-linked dopamine D2-receptor action in prefrontal cortex.
    Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1964-9 PMID: 11172059
  53. Aged monkeys exhibit behavioral deficits indicative of widespread cerebral dysfunction.
    Neurobiol Aging. 1991 Mar-Apr;12(2):99-111 PMID: 2052134
  54. D1 dopamine receptor immunoreactivity in human and monkey cerebral cortex: predominant and extrasynaptic localization in dendritic spines.
    Proc Natl Acad Sci U S A. 1994 Jun 7;91(12):5720-4 PMID: 7911245
  55. Evidence for striatal dopamine release during a video game.
    Nature. 1998 May 21;393(6682):266-8 PMID: 9607763
  56. Bidirectional dopamine modulation of GABAergic inhibition in prefrontal cortical pyramidal neurons.
    J Neurosci. 2001 May 15;21(10):3628-38 PMID: 11331392
  57. Dorsolateral prefrontal lesions and oculomotor delayed-response performance: evidence for mnemonic "scotomas".
    J Neurosci. 1993 Apr;13(4):1479-97 PMID: 8463830
  58. A comparison of plasma homovanillic acid concentrations in schizophrenic patients and normal controls.
    Arch Gen Psychiatry. 1988 Jun;45(6):561-3 PMID: 3377642
  59. Dose-dependent effects of the dopamine D1 receptor agonists A77636 or SKF81297 on spatial working memory in aged monkeys.
    J Pharmacol Exp Ther. 1997 Oct;283(1):183-9 PMID: 9336323
  60. Dysfunctional brain dopamine systems induced by psychotomimetic NMDA-receptor antagonists and the effects of antipsychotic drugs.
    Brain Res Brain Res Rev. 2000 Mar;31(2-3):320-9 PMID: 10719159
  61. Enhancement of working memory in aged monkeys by a sensitizing regimen of dopamine D1 receptor stimulation.
    J Neurosci. 2004 Feb 11;24(6):1446-50 PMID: 14960617
  62. What are the functional consequences of neurocognitive deficits in schizophrenia?
    Am J Psychiatry. 1996 Mar;153(3):321-30 PMID: 8610818
  63. Altered frontal cortical dopaminergic transmission in monkeys after subchronic phencyclidine exposure: involvement in frontostriatal cognitive deficits.
    Neuroscience. 1999 Mar;90(3):823-32 PMID: 10218783
  64. Symptoms and neurocognition as rate limiters in skills training for psychotic patients.
    Am J Psychiatry. 1999 Nov;156(11):1817-8 PMID: 10553750
  65. Coupling of human D-1 dopamine receptors to different guanine nucleotide binding proteins. Evidence that D-1 dopamine receptors can couple to both Gs and G(o).
    J Biol Chem. 1995 Jun 16;270(24):14672-8 PMID: 7782330
  66. Implications of normal brain development for the pathogenesis of schizophrenia.
    Arch Gen Psychiatry. 1987 Jul;44(7):660-9 PMID: 3606332
  67. Dopamine D1 receptor actions in layers V-VI rat prefrontal cortex neurons in vitro: modulation of dendritic-somatic signal integration.
    J Neurosci. 1996 Mar 1;16(5):1922-35 PMID: 8774459
  68. SKF83959 selectively regulates phosphatidylinositol-linked D1 dopamine receptors in rat brain.
    J Neurochem. 2003 Apr;85(2):378-86 PMID: 12675914
  69. Neuropsychology. Is dopamine a missing link?
    Nature. 1995 Aug 17;376(6541):549-50 PMID: 7637797
  70. Abnormally high neuronal density in the schizophrenic cortex. A morphometric analysis of prefrontal area 9 and occipital area 17.
    Arch Gen Psychiatry. 1995 Oct;52(10):805-18; discussion 819-20 PMID: 7575100
  71. Decreased density of tyrosine hydroxylase-immunoreactive axons in the entorhinal cortex of schizophrenic subjects.
    Biol Psychiatry. 2000 Mar 1;47(5):361-70 PMID: 10704948
  72. Dopamine transmission in the initiation and expression of drug- and stress-induced sensitization of motor activity.
    Brain Res Brain Res Rev. 1991 Sep-Dec;16(3):223-44 PMID: 1665095
  73. Aging in the rhesus monkey: debilitating effects on short-term memory.
    J Gerontol. 1978 Nov;33(6):858-71 PMID: 106081
  74. Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder.
    Neuropsychopharmacology. 2002 Nov;27(5):699-711 PMID: 12431845
  75. Cognitive impairment in schizophrenia is the core of the disorder.
    Crit Rev Neurobiol. 2000;14(1):1-21 PMID: 11253953
  76. Cognitive and motor deficits in the acquisition of an object retrieval/detour task in MPTP-treated monkeys.
    Brain. 1990 Jun;113 ( Pt 3):617-37 PMID: 2364263
  77. The relationship between dorsolateral prefrontal neuronal N-acetylaspartate and evoked release of striatal dopamine in schizophrenia.
    Neuropsychopharmacology. 2000 Feb;22(2):125-32 PMID: 10649825
  78. Multiple coupling of human D5 dopamine receptors to guanine nucleotide binding proteins Gs and Gz.
    J Neurochem. 1998 Jun;70(6):2459-67 PMID: 9603210
  79. Effects of dextroamphetamine on cognitive performance and cortical activation.
    Neuroimage. 2000 Sep;12(3):268-75 PMID: 10944409
  80. Age-dependent decline in human brain dopamine D1 and D2 receptors.
    Brain Res. 1990 Feb 5;508(2):349-52 PMID: 2407314
  81. Catechol-O-methyltransferase genotype and dopamine regulation in the human brain.
    J Neurosci. 2003 Mar 15;23(6):2008-13 PMID: 12657658
  82. Catechol-O-methyltransferase gene polymorphism in schizophrenia: evidence for association between symptomatology and prognosis.
    Psychiatr Genet. 2001 Jun;11(2):105-9 PMID: 11525417
  83. Functional hypofrontality and working memory dysfunction in schizophrenia.
    Am J Psychiatry. 1998 Sep;155(9):1285-7 PMID: 9734557
  84. Interaction of dopamine D1 and NMDA receptors mediates acute clozapine potentiation of glutamate EPSPs in rat prefrontal cortex.
    J Neurophysiol. 2002 May;87(5):2324-36 PMID: 11976371
  85. Cognitive function and biological correlates of cognitive performance in schizotypal personality disorder.
    Psychiatry Res. 1995 Nov 29;59(1-2):127-36 PMID: 8771227
  86. Brain dopamine receptors: a primer on their current status, basic and clinical.
    Harv Rev Psychiatry. 1996 Mar-Apr;3(6):301-25 PMID: 9384962
  87. Getting formal with dopamine and reward.
    Neuron. 2002 Oct 10;36(2):241-63 PMID: 12383780
  88. Amphetamine sensitization of hallucinatory-like behaviors is dependent on prefrontal cortex in nonhuman primates.
    Biol Psychiatry. 2003 Jul 15;54(2):105-10 PMID: 12873799
  89. Dual signaling regulated by calcyon, a D1 dopamine receptor interacting protein.
    Science. 2000 Mar 3;287(5458):1660-4 PMID: 10698743
  90. Enhanced and impaired attentional performance after infusion of D1 dopaminergic receptor agents into rat prefrontal cortex.
    J Neurosci. 2000 Feb 1;20(3):1208-15 PMID: 10648725
  91. Lamina-specific alterations in the dopamine innervation of the prefrontal cortex in schizophrenic subjects.
    Am J Psychiatry. 1999 Oct;156(10):1580-9 PMID: 10518170
  92. Dopaminergic modulation of visual-spatial working memory in Parkinson's disease.
    Dement Geriatr Cogn Disord. 2003;15(2):55-66 PMID: 12566593
  93. Dopamine receptors and the dopamine hypothesis of schizophrenia.
    Synapse. 1987;1(2):133-52 PMID: 2905529
  94. Effects of amphetamine on visuospatial working memory performance in schizophrenia spectrum personality disorder.
    Neuropsychopharmacology. 2000 Jan;22(1):14-8 PMID: 10633486
  95. Frontal dysfunction of chronic schizophrenia--the pros and cons in neuropsychological assessment.
    Yakubutsu Seishin Kodo. 1991 Feb;11(1):83-8 PMID: 1882592
  96. Cognition, schizophrenia, and the atypical antipsychotic drugs.
    Proc Natl Acad Sci U S A. 1999 Nov 23;96(24):13591-3 PMID: 10570115
  97. Enduring cognitive deficits and cortical dopamine dysfunction in monkeys after long-term administration of phencyclidine.
    Science. 1997 Aug 15;277(5328):953-5 PMID: 9252326
  98. Physiological dysfunction of the dorsolateral prefrontal cortex in schizophrenia revisited.
    Cereb Cortex. 2000 Nov;10(11):1078-92 PMID: 11053229
  99. D-amphetamine challenge effects on Wisconsin Card Sort Test. Performance in schizotypal personality disorder.
    Schizophr Res. 1996 May;20(1-2):29-32 PMID: 8794491
  100. Delayed matching-to-sample, object retrieval, and discrimination reversal deficits in chronic low dose MPTP-treated monkeys.
    Brain Res. 1993 Jul 2;615(2):351-4 PMID: 8364742
  101. Isodirectional tuning of adjacent interneurons and pyramidal cells during working memory: evidence for microcolumnar organization in PFC.
    J Neurophysiol. 1999 Apr;81(4):1903-16 PMID: 10200225
  102. Effects of neuromodulation in a cortical network model of object working memory dominated by recurrent inhibition.
    J Comput Neurosci. 2001 Jul-Aug;11(1):63-85 PMID: 11524578
  103. The physiological approach: functional architecture of working memory and disordered cognition in schizophrenia.
    Biol Psychiatry. 1999 Sep 1;46(5):650-61 PMID: 10472417
  104. Distribution of dopaminergic receptors in the primate cerebral cortex: quantitative autoradiographic analysis using [3H]raclopride, [3H]spiperone and [3H]SCH23390.
    Neuroscience. 1991;40(3):657-71 PMID: 2062437
  105. Age-related changes in multiple neurotransmitter systems in the monkey brain.
    Neurobiol Aging. 1989 Jan-Feb;10(1):11-9 PMID: 2569169
  106. Clozapine preferentially increases dopamine release in the rhesus monkey prefrontal cortex compared with the caudate nucleus.
    Neuropsychopharmacology. 1999 May;20(5):403-12 PMID: 10192821
  107. Reversal of antipsychotic-induced working memory deficits by short-term dopamine D1 receptor stimulation.
    Science. 2000 Mar 17;287(5460):2020-2 PMID: 10720329
  108. 5-HT(2A) and D(2) receptor blockade increases cortical DA release via 5-HT(1A) receptor activation: a possible mechanism of atypical antipsychotic-induced cortical dopamine release.
    J Neurochem. 2001 Mar;76(5):1521-31 PMID: 11238736
  109. Up-regulation of the D1 dopamine receptor-interacting protein, calcyon, in patients with schizophrenia.
    Arch Gen Psychiatry. 2003 Mar;60(3):311-9 PMID: 12622665
  110. Nicotinic acetylcholine receptor agonist SIB-1508Y improves cognitive functioning in chronic low-dose MPTP-treated monkeys.
    J Pharmacol Exp Ther. 1999 Aug;290(2):731-9 PMID: 10411585
  111. Performance on the Wisconsin Card Sorting Test as a predictor of rehospitalization in schizophrenia.
    J Nerv Ment Dis. 1996 May;184(5):319-21 PMID: 8627280
  112. Dopaminergic modulation of cortical function in patients with Parkinson's disease.
    Ann Neurol. 2002 Feb;51(2):156-64 PMID: 11835371
  113. Neurocognitive correlates of the COMT Val(158)Met polymorphism in chronic schizophrenia.
    Biol Psychiatry. 2002 Oct 1;52(7):701-7 PMID: 12372660
  114. Relationship between catechol-O-methyltransferase polymorphism and treatment-resistant schizophrenia.
    Am J Med Genet B Neuropsychiatr Genet. 2003 Jul 1;120B(1):35-9 PMID: 12815736
  115. Cortical dysfunction in schizophrenia during auditory word and tone working memory demonstrated by functional magnetic resonance imaging.
    Arch Gen Psychiatry. 1998 Dec;55(12):1097-103 PMID: 9862553
  116. The nature of interactions involving prefrontal and striatal dopamine systems.
    J Psychopharmacol. 1997;11(2):143-50 PMID: 9208377
  117. Dopamine controls fundamental cognitive operations of multi-target spatial working memory.
    Neural Netw. 2002 Jun-Jul;15(4-6):573-82 PMID: 12371513
  118. The computational role of dopamine D1 receptors in working memory.
    Neural Netw. 2002 Jun-Jul;15(4-6):561-72 PMID: 12371512
  119. Cognitive deficit caused by regional depletion of dopamine in prefrontal cortex of rhesus monkey.
    Science. 1979 Aug 31;205(4409):929-32 PMID: 112679
  120. Spatial working memory deficits and clinical symptoms in schizophrenia: a 4-month follow-up study.
    Biol Psychiatry. 1999 Aug 1;46(3):392-400 PMID: 10435205
  121. Dopamine D2 receptor mechanisms contribute to age-related cognitive decline: the effects of quinpirole on memory and motor performance in monkeys.
    J Neurosci. 1995 May;15(5 Pt 1):3429-39 PMID: 7751922
  122. Long-lasting psychotomimetic consequences of repeated low-dose amphetamine exposure in rhesus monkeys.
    Neuropsychopharmacology. 1999 Jan;20(1):10-28 PMID: 9885781
  123. Dopaminergic modulation of high-level cognition in Parkinson's disease: the role of the prefrontal cortex revealed by PET.
    Brain. 2002 Mar;125(Pt 3):584-94 PMID: 11872615
  124. Reduced prefrontal activity predicts exaggerated striatal dopaminergic function in schizophrenia.
    Nat Neurosci. 2002 Mar;5(3):267-71 PMID: 11865311
  125. Age-dependent decline of dopamine D1 receptors in human brain: a PET study.
    Synapse. 1998 Sep;30(1):56-61 PMID: 9704881
  126. The relationship between dorsolateral prefrontal N-acetylaspartate measures and striatal dopamine activity in schizophrenia.
    Biol Psychiatry. 1999 Mar 15;45(6):660-7 PMID: 10187995
  127. Dopamine as the wind of the psychotic fire: new evidence from brain imaging studies.
    J Psychopharmacol. 1999 Dec;13(4):358-71 PMID: 10667612
  128. Binding of 3H-neuroleptics and 3H-apomorphine in schizophrenic brains.
    Nature. 1978 Aug 31;274(5674):897-900 PMID: 683328
  129. Electrophysiological and morphological analyses of cortical neurons obtained from children with catastrophic epilepsy: dopamine receptor modulation of glutamatergic responses.
    Dev Neurosci. 1999 Nov;21(3-5):223-35 PMID: 10575246
  130. D1 receptor alleles predict PET metabolic correlates of clinical response to clozapine.
    Mol Psychiatry. 2003 Jan;8(1):109-13 PMID: 12556915
  131. Dopamine enhances the neuronal activity of spatial short-term memory task in the primate prefrontal cortex.
    Neurosci Res. 1988 Jun;5(5):465-73 PMID: 3399149
  132. Modulation of calcium currents by a D1 dopaminergic protein kinase/phosphatase cascade in rat neostriatal neurons.
    Neuron. 1995 Feb;14(2):385-97 PMID: 7531987
  133. Single photon emission computerized tomography imaging of amphetamine-induced dopamine release in drug-free schizophrenic subjects.
    Proc Natl Acad Sci U S A. 1996 Aug 20;93(17 ):9235-40 PMID: 8799184
  134. The effect of aging on the D1 dopamine receptors in human frontal cortex.
    Brain Res. 1990 Oct 1;528(2):308-10 PMID: 2148706
  135. Endogenous dopamine potentiates the effects of glutamate on extracellular GABA in the prefrontal cortex of the freely moving rat.
    Brain Res Bull. 2000 Oct;53(3):339-45 PMID: 11113590
  136. Presynaptic regulation of recurrent excitation by D1 receptors in prefrontal circuits.
    Proc Natl Acad Sci U S A. 2001 Jan 2;98(1):295-300 PMID: 11134520
  137. Synaptic regulation of mesocorticolimbic dopamine neurons.
    Annu Rev Neurosci. 1996;19:405-36 PMID: 8833449
  138. Biochemical characteristics of D1 dopamine receptors: relationship to behavior and schizophrenia.
    Clin Neuropharmacol. 1986;9 Suppl 4:14-6 PMID: 2882838
  139. Noradrenaline reuptake inhibition enhances the antipsychotic-like effect of raclopride and potentiates D2-blockage-induced dopamine release in the medial prefrontal cortex of the rat.
    Neuropsychopharmacology. 2002 Nov;27(5):691-8 PMID: 12431844
  140. Enduring changes in brain and behavior produced by chronic amphetamine administration: a review and evaluation of animal models of amphetamine psychosis.
    Brain Res. 1986 Jun;396(2):157-98 PMID: 3527341
  141. Prominence of the dopamine D2 short isoform in dopaminergic pathways.
    Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7731-6 PMID: 9636219
  142. The role of cognition in vocational functioning in schizophrenia.
    Schizophr Res. 2000 Oct 27;45(3):175-84 PMID: 11042435
  143. Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia. I. Regional cerebral blood flow evidence.
    Arch Gen Psychiatry. 1986 Feb;43(2):114-24 PMID: 3947207
  144. Increased brain dopamine and dopamine receptors in schizophrenia.
    Arch Gen Psychiatry. 1982 Sep;39(9):991-7 PMID: 7115016
  145. Visuospatial memory deficits at different stages of Parkinson's disease.
    Neuropsychologia. 1993 Jul;31(7):627-44 PMID: 8371837
  146. Association of storage and processing functions in the dorsolateral prefrontal cortex of the nonhuman primate.
    J Neurosci. 1999 Jun 15;19(12):5149-58 PMID: 10366648
  147. Mnemonic coding of visual space in the monkey's dorsolateral prefrontal cortex.
    J Neurophysiol. 1989 Feb;61(2):331-49 PMID: 2918358
  148. Executive function profile of children with attention deficit hyperactivity disorder.
    Dev Neuropsychol. 2002;21(1):43-71 PMID: 12058835
  149. The cerebral cortex: a case for a common site of action of antipsychotics.
    Trends Pharmacol Sci. 1998 Apr;19(4):136-40 PMID: 9612088
  150. Anterior cingulate gyrus dysfunction and selective attention deficits in schizophrenia: [15O]H2O PET study during single-trial Stroop task performance.
    Am J Psychiatry. 1997 Dec;154(12 ):1670-5 PMID: 9396944
  151. 5-HT(2A) receptor antagonism potentiates haloperidol-induced dopamine release in rat medial prefrontal cortex and inhibits that in the nucleus accumbens in a dose-dependent manner.
    Brain Res. 2002 Aug 30;947(2):157-65 PMID: 12176156
  152. The role of D1-dopamine receptor in working memory: local injections of dopamine antagonists into the prefrontal cortex of rhesus monkeys performing an oculomotor delayed-response task.
    J Neurophysiol. 1994 Feb;71(2):515-28 PMID: 7909839
  153. D1- versus D2-receptor modulation of visuospatial working memory in humans.
    J Neurosci. 1998 Apr 1;18(7):2720-8 PMID: 9502829
  154. Increased dopamine transmission in schizophrenia: relationship to illness phases.
    Biol Psychiatry. 1999 Jul 1;46(1):56-72 PMID: 10394474
  155. Inhibitory effects of ventral tegmental area stimulation on the activity of prefrontal cortical neurons: evidence for the involvement of both dopaminergic and GABAergic components.
    Neuroscience. 1992 Aug;49(4):857-65 PMID: 1436485
  156. EFFECT OF CHLORPROMAZINE OR HALOPERIDOL ON FORMATION OF 3METHOXYTYRAMINE AND NORMETANEPHRINE IN MOUSE BRAIN.
    Acta Pharmacol Toxicol (Copenh). 1963;20:140-4 PMID: 14060771
  157. Evidence for selective involvement of dopamine D1 receptors of the ventral tegmental area in the behavioral sensitization induced by intra-ventral tegmental area injections of D-amphetamine.
    J Pharmacol Exp Ther. 1996 May;277(2):1177-87 PMID: 8627530
  158. Memory of monkeys (Macaca mulatta) with lesions in prefrontal cortex.
    Behav Neurosci. 1985 Feb;99(1):3-21 PMID: 4041231
  159. D(1) dopamine receptors potentiate nmda-mediated excitability increase in layer V prefrontal cortical pyramidal neurons.
    Cereb Cortex. 2001 May;11(5):452-62 PMID: 11313297
  160. PET study of D(1) dopamine receptor binding in neuroleptic-naive patients with schizophrenia.
    Am J Psychiatry. 2002 May;159(5):761-7 PMID: 11986129
  161. Age-related changes in the striatal dopaminergic system in the living brain: a multiparametric PET study in conscious monkeys.
    Synapse. 2002 Jul;45(1):38-45 PMID: 12112412
  162. Delayed-matching and delayed-response deficit from cooling dorsolateral prefrontal cortex in monkeys.
    J Comp Physiol Psychol. 1976 Mar;90(3):293-302 PMID: 819472
  163. Adult attention-deficit/hyperactivity disorder: neuropsychological correlates and clinical presentation.
    Brain Cogn. 2001 Jun-Jul;46(1-2):114-21 PMID: 11527308
  164. Effects of dopamine antagonists on neuronal activity related to a delayed response task in monkey prefrontal cortex.
    J Neurophysiol. 1990 Jun;63(6):1401-12 PMID: 2358883
  165. Spatial memory improvement by levodopa in parkinsonian MPTP-treated monkeys.
    Psychopharmacology (Berl). 1999 Nov;147(1):104-7 PMID: 10591875
  166. The relative influences of symptoms, insight, and neurocognition on social adjustment in schizophrenia and schizoaffective disorder.
    J Nerv Ment Dis. 1999 Feb;187(2):102-8 PMID: 10067950
  167. Visual and oculomotor functions of monkey substantia nigra pars reticulata. III. Memory-contingent visual and saccade responses.
    J Neurophysiol. 1983 May;49(5):1268-84 PMID: 6864250
  168. Pharmacological and biochemical evidence for the existence of two categories of dopamine receptor.
    Can J Neurol Sci. 1984 Feb;11(1 Suppl):114-7 PMID: 6324982
  169. Age-related changes in human D1 dopamine receptors measured by positron emission tomography.
    Psychopharmacology (Berl). 1991;103(1):41-5 PMID: 1826059
  170. Effects of dopamine agonists on delayed response performance in chronic low-dose MPTP-treated monkeys.
    Pharmacol Biochem Behav. 1994 May;48(1):235-40 PMID: 7913226
  171. Spatial memory deficits in aged rats: contributions of monoaminergic systems.
    Brain Res. 1990 Dec 24;537(1-2):271-8 PMID: 2085779
  172. Receptor activity and turnover of dopamine and noradrenaline after neuroleptics.
    Eur J Pharmacol. 1970;11(3):303-14 PMID: 5477307
  173. Evidence for the coupling of Gq protein to D1-like dopamine sites in rat striatum: possible role in dopamine-mediated inositol phosphate formation.
    Mol Pharmacol. 1995 Dec;48(6):988-94 PMID: 8848015
  174. Schizophrenics show spatial working memory deficits.
    Arch Gen Psychiatry. 1992 Dec;49(12):975-82 PMID: 1449384
  175. Developing a neuronal model for the pathophysiology of schizophrenia based on the nature of electrophysiological actions of dopamine in the prefrontal cortex.
    Neuropsychopharmacology. 1999 Aug;21(2):161-94 PMID: 10432466
  176. D1 dopamine receptor activation is necessary for the induction of sensitization by amphetamine in the ventral tegmental area.
    J Neurosci. 1996 Apr 1;16(7):2411-20 PMID: 8601820
  177. Positron emission tomography reveals elevated D2 dopamine receptors in drug-naive schizophrenics.
    Science. 1986 Dec 19;234(4783):1558-63 PMID: 2878495
  178. Age-related and regional differences in dopamine transporter mRNA expression in human midbrain.
    Neurology. 1997 Apr;48(4):969-77 PMID: 9109886
  179. Cellular distribution of dopamine D1 and D2 receptors in rat medial prefrontal cortex.
    J Neurosci. 1993 Jun;13(6):2551-64 PMID: 8501521
  180. Prolonged and extrasynaptic excitatory action of dopamine mediated by D1 receptors in the rat striatum in vivo.
    J Neurosci. 1997 Aug 1;17(15):5972-8 PMID: 9221793
  181. Long-term cognitive impairment in MPTP-treated rhesus monkeys.
    Neuroreport. 1995 Dec 29;7(1):102-4 PMID: 8742427
  182. Dopamine depletion and in vivo binding of PET D1 receptor radioligands: implications for imaging studies in schizophrenia.
    Neuropsychopharmacology. 2003 Sep;28(9):1703-11 PMID: 12813475
  183. Outcome in schizophrenia: beyond symptom reduction.
    J Clin Psychiatry. 1999;60 Suppl 3:3-7; discussion 8 PMID: 10073370
  184. Neonatal lesions of the medial temporal lobe disrupt prefrontal cortical regulation of striatal dopamine.
    Nature. 1998 May 14;393(6681):169-71 PMID: 9603519
  185. Increased striatal dopamine transmission in schizophrenia: confirmation in a second cohort.
    Am J Psychiatry. 1998 Jun;155(6):761-7 PMID: 9619147
  186. Cognitive function in schizophrenia.
    Int Clin Psychopharmacol. 1997 Sep;12 Suppl 4:S29-36 PMID: 9352344
  187. Inhibitory influence of the mesocortical dopaminergic neurons on their target cells: electrophysiological and pharmacological characterization.
    J Pharmacol Exp Ther. 1991 Aug;258(2):728-38 PMID: 1865369
  188. Linking mind and brain in the study of mental illnesses: a project for a scientific psychopathology.
    Science. 1997 Mar 14;275(5306):1586-93 PMID: 9054346
  189. L-dopa withdrawal in Parkinson's disease selectively impairs cognitive performance in tests sensitive to frontal lobe dysfunction.
    Psychopharmacology (Berl). 1992;107(2-3):394-404 PMID: 1615139
  190. A functional polymorphism in the COMT gene and performance on a test of prefrontal cognition.
    Am J Psychiatry. 2002 Apr;159(4):652-4 PMID: 11925305
Article Info
Journal
Psychopharmacology
Abbr.
Psychopharmacology (Berl)
ISSN
0033-3158
DOI
10.1007/s00213-004-1793-y
Published
2004-06-00
Epub
2004-00-30
Pages
3-16
Language
English
Region
Germany
NLM ID
7608025
Subset
IM
External Links
PubMed source DOI: 10.1007/s00213-004-1793-y View journal details
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