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PMID: 15140938 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

The function of neurotrophic factor receptors expressed by the developing adductor motor pool in vivo.

The Journal of neuroscience : the official journal of the Society for Neuroscience ·Vol. 24 ·No. 19 ·2004-05-12 ·Pages 4668-82

Gould TW, Oppenheim RW

Abstract

We examined the spatio-temporal relationship between neurotrophic factor receptor (NTF-R) expression and motoneuron (MN) survival in the developing avian spinal cord and observed heterogeneity in the expression of NTF-Rs between, but not within, pools of MNs projecting to individual muscles. We then focused on the role of NTFs in regulating the survival of one motor pool of MNs, all of which innervate a pair of adductor muscles in the thigh and hence compete for survival during the period of programmed cell death (PCD). The complete NTF-R complement of these MNs was analyzed and found to include many, but not all, NTF-Rs. Treatment with exogenous individual NTFs rescued some, but not all, adductor MNs expressing appropriate NTF-Rs. In contrast, administration of multiple NTFs completely rescued adductor MNs from PCD. Additionally, adductor MNs were partially rescued from PCD by NTFs for which they failed to express receptors. NTF-Rs expressed by the nerve but not in the muscle target were capable of mediating survival signals to MNs in trans. Finally, the expression of some NTF-Rs by adductor MNs was not required for MN survival. These studies demonstrate the complexity in NTF regulation of a defined subset of competing MNs and suggest that properties other than NTF-R expression itself can play a role in mediating trophic responses to NTFs.

MeSH Terms
Animals Apoptosis/drug effects,physiology Cell Survival/drug effects,physiology Chick Embryo Ciliary Neurotrophic Factor/antagonists & inhibitors,pharmacology Glial Cell Line-Derived Neurotrophic Factor Hindlimb/embryology,innervation Ligands Motor Neurons/cytology,drug effects,metabolism Muscle, Skeletal/embryology,innervation Nerve Growth Factors/antagonists & inhibitors,pharmacology Receptors, Nerve Growth Factor/antagonists & inhibitors,biosynthesis,physiology Signal Transduction/drug effects,physiology Spinal Cord/cytology,embryology,metabolism
Chemicals
Ciliary Neurotrophic Factor Glial Cell Line-Derived Neurotrophic Factor Ligands Nerve Growth Factors Receptors, Nerve Growth Factor
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Gould Thomas W
Department of Neurobiology and Anatomy and Neuroscience Program, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA.
Oppenheim Ronald W
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Article Info
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
Abbr.
J Neurosci
ISSN
1529-2401
DOI
10.1523/JNEUROSCI.0580-04.2004
Published
2004-05-12
Pages
4668-82
Language
English
Region
United States
NLM ID
8102140
PMCID
PMC6729401
Subset
IM
Grants
NINDS NIH HHS · R01 NS020402 · United States
NINDS NIH HHS · NS20402 · United States
External Links
PubMed source DOI: 10.1523/JNEUROSCI.0580-04.2004 PMC Full Text View journal details
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