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PMID: 15148331 Published · ppublish English Journal Article Review

Human Mannose-binding Lectin in Immunity: Friend, Foe, or Both?

The Journal of experimental medicine ·Vol. 199 ·No. 10 ·2004-05-17 ·Pages 1295-9

Casanova JL, Abel L

Abstract

Human mannose-binding lectin (MBL) recognizes a wide range of microorganisms and triggers the most ancient pathway of complement activation. However, approximately 5% of individuals lack functional serum MBL and have not been found to be prone to severe infections in prospective studies. These data suggest that human MBL is largely redundant for protective immunity and may even have been subject to counter selection because of a deleterious impact.

MeSH Terms
Animals Geography Haplotypes Humans Immunity Infections/immunology Mannose-Binding Lectin/deficiency,genetics,immunology Mice Models, Animal
Chemicals
Mannose-Binding Lectin
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Casanova Jean-Laurent
Pediatric Hematology-Immunology Unit, Necker Enfants-Malades Hospital, Paris, France. [email protected]
Abel Laurent
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.20040537
Email
[email protected]
Published
2004-05-17
Pages
1295-9
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2211810
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.20040537 PMC Full Text View journal details
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