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PMID: 15173120 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

WebLogo: a sequence logo generator.

Genome research ·Vol. 14 ·No. 6 ·2004-06-00 ·Pages 1188-90

Crooks GE, Hon G, Chandonia JM, Brenner SE

Abstract

WebLogo generates sequence logos, graphical representations of the patterns within a multiple sequence alignment. Sequence logos provide a richer and more precise description of sequence similarity than consensus sequences and can rapidly reveal significant features of the alignment otherwise difficult to perceive. Each logo consists of stacks of letters, one stack for each position in the sequence. The overall height of each stack indicates the sequence conservation at that position (measured in bits), whereas the height of symbols within the stack reflects the relative frequency of the corresponding amino or nucleic acid at that position. WebLogo has been enhanced recently with additional features and options, to provide a convenient and highly configurable sequence logo generator. A command line interface and the complete, open WebLogo source code are available for local installation and customization.

MeSH Terms
Amino Acid Sequence Base Sequence Computer Graphics Cyclic AMP Receptor Protein/chemistry DNA, Bacterial/chemistry Escherichia coli Proteins/chemistry Internet Nucleic Acid Conformation Protein Structure, Quaternary Software
Chemicals
Cyclic AMP Receptor Protein DNA, Bacterial Escherichia coli Proteins
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Crooks Gavin E
Department of Plant and Microbial Biology, University of California, Berkeley, California 94720, USA.
Hon Gary
Chandonia John-Marc
Brenner Steven E
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Article Info
Journal
Genome research
Abbr.
Genome Res
ISSN
1088-9051
DOI
10.1101/gr.849004
Published
2004-06-00
Pages
1188-90
Language
English
Region
United States
NLM ID
9518021
PMCID
PMC419797
Subset
IM
Grants
NHGRI NIH HHS · K22 HG000056 · United States
NIGMS NIH HHS · P50 GM062412 · United States
NHGRI NIH HHS · 1-K22-HG00056 · United States
NIGMS NIH HHS · 1-P50-GM62412 · United States
External Links
PubMed source DOI: 10.1101/gr.849004 PMC Full Text View journal details
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