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PMID: 15220357 Published · ppublish English Journal Article Review

My approach to serrated polyps of the colorectum.

Journal of clinical pathology ·Vol. 57 ·No. 7 ·2004-07-00 ·Pages 682-6

Higuchi T, Jass JR

Abstract

Hyperplastic polyps of the colorectum are heterogeneous lesions, a subset of which is now regarded as the precursor of colorectal cancer with DNA microsatellite instability. Some authors have distinguished this subset from classic hyperplastic polyps and have introduced the term "sessile serrated adenoma". These lesions frequently show BRAF mutation and DNA methylation. This personal perspective reviews recent insights into serrated polyps and highlights the importance of inhibition of apoptosis as a unifying mechanism. It is estimated that around 25 hyperplastic polyps of the proximal colon exist for every colorectal cancer with DNA microsatellite instability. Further research is required to identify additional risk factors for hyperplastic polyps other than anatomical location. These may be demographic, clinical, morphological, or molecular. It is not recommended that the term sessile serrated adenoma be used in routine reporting, but it is desirable that potentially aggressive hyperplastic polyps should be identified for the purposes of both clinical practice and research.

MeSH Terms
Colorectal Neoplasms/pathology Humans Hyperplasia Intestinal Polyps/pathology Precancerous Conditions/pathology Risk Factors Terminology as Topic
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Higuchi T
Department of Digestive Surgery, Tokyo Medical and Dental University, Tokyo, Japan.
Jass J R
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Article Info
Journal
Journal of clinical pathology
Abbr.
J Clin Pathol
ISSN
0021-9746
DOI
10.1136/jcp.2003.015230
Published
2004-07-00
Pages
682-6
Language
English
Region
England
NLM ID
0376601
PMCID
PMC1770365
Subset
IM
External Links
PubMed source DOI: 10.1136/jcp.2003.015230 PMC Full Text View journal details
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