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PMID: 1522219 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Induction of antiphospholipid autoantibodies by immunization with beta 2 glycoprotein I (apolipoprotein H).

The Journal of clinical investigation ·Vol. 90 ·No. 3 ·1992-09-00 ·Pages 1105-9

Gharavi AE, Sammaritano LR, Wen J, Elkon KB

Abstract

A subset of patients with systemic lupus erythematosus has autoantibodies to acidic phospholipids. Since lipids are poor immunogens, the mechanism responsible for the induction of these antibodies is unclear. Immunization of a normal rabbit and normal mice with purified human beta 2-glycoprotein I (apolipoprotein H) resulted in the production of high levels of two non-cross-reactive antibody populations, anti-apolipoprotein H, and antiphospholipid. The antiphospholipid antibodies had binding specificities indistinguishable from autoantibodies obtained from human and murine lupus. These findings suggest a novel mechanism for the induction of antiphospholipid autoantibodies.

MeSH Terms
Animals Apolipoproteins/immunology Autoantibodies/biosynthesis Cattle Glycoproteins/immunology Humans Immunization Mice Phospholipids/immunology Rabbits beta 2-Glycoprotein I
Chemicals
Apolipoproteins Autoantibodies Glycoproteins Phospholipids beta 2-Glycoprotein I
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Gharavi A E
Division of Rheumatic Diseases, Hospital for Special Surgery-Cornell University Medical Center, New York 10021.
Sammaritano L R
Wen J
Elkon K B
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Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/JCI115927
Published
1992-09-00
Pages
1105-9
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC329971
Subset
IM
Grants
NIAMS NIH HHS · AR-38915 · United States
External Links
PubMed source DOI: 10.1172/JCI115927 PMC Full Text View journal details
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