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PMID: 15241415 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Genesis of a highly pathogenic and potentially pandemic H5N1 influenza virus in eastern Asia.

Nature ·Vol. 430 ·No. 6996 ·2004-07-08 ·Pages 209-13

Li KS, Guan Y, Wang J, Smith GJ, Xu KM, Duan L, Rahardjo AP, Puthavathana P, Buranathai C, Nguyen TD, Estoepangestie AT, Chaisingh A, Auewarakul P, Long HT, Hanh NT, Webby RJ, Poon LL, Chen H, Shortridge KF, Yuen KY, Webster RG, Peiris JS

Abstract

A highly pathogenic avian influenza virus, H5N1, caused disease outbreaks in poultry in China and seven other east Asian countries between late 2003 and early 2004; the same virus was fatal to humans in Thailand and Vietnam. Here we demonstrate a series of genetic reassortment events traceable to the precursor of the H5N1 viruses that caused the initial human outbreak in Hong Kong in 1997 (refs 2-4) and subsequent avian outbreaks in 2001 and 2002 (refs 5, 6). These events gave rise to a dominant H5N1 genotype (Z) in chickens and ducks that was responsible for the regional outbreak in 2003-04. Our findings indicate that domestic ducks in southern China had a central role in the generation and maintenance of this virus, and that wild birds may have contributed to the increasingly wide spread of the virus in Asia. Our results suggest that H5N1 viruses with pandemic potential have become endemic in the region and are not easily eradicable. These developments pose a threat to public and veterinary health in the region and potentially the world, and suggest that long-term control measures are required.

MeSH Terms

Animals Birds/virology Evolution, Molecular Far East/epidemiology Genes, Viral/genetics Genotype Humans Influenza, Human/epidemiology,transmission,virology Molecular Sequence Data Mutation/genetics Orthomyxoviridae/genetics,isolation & purification,pathogenicity Phylogeny Reassortant Viruses/genetics,isolation & purification,pathogenicity Time Factors

Authors & Affiliations

22 authors, click to expand affiliations / ORCID

Li K S

Joint Influenza Research Centre (SUMC & HKU), Shantou University Medical College, Shantou, Guangdong 515031, China.

Guan Y

Wang J

Smith G J D

Xu K M

Duan L

Rahardjo A P

Puthavathana P

Buranathai C

Nguyen T D

Estoepangestie A T S

Chaisingh A

Auewarakul P

Long H T

Hanh N T H

Webby R J

Poon L L M

Chen H

Shortridge K F

Yuen K Y

Webster R G

Peiris J S M

Article Info

Journal

Nature

Abbr.

Nature

ISSN

1476-4687

DOI

10.1038/nature02746

Published

2004-07-08

Pages

209-13

Language

English

Region

England

NLM ID

0410462

Subset

Databases

GENBANK

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PubMed source DOI: 10.1038/nature02746 View journal details

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Genesis of a highly pathogenic and potentially pandemic H5N1 influenza virus in eastern Asia.

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