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PMID: 15249682 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Pattern of polymorphism after strong artificial selection in a domestication event.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 101 ·No. 29 ·2004-07-20 ·Pages 10667-72

Innan H, Kim Y

Abstract

The process of strong artificial selection during a domestication event is modeled, and its effect on the pattern of DNA polymorphism is investigated. The model also considers population bottleneck during domestication. Artificial selection during domestication is different from a regular selective sweep because artificial selection acts on alleles that may have been neutral variants before domestication. Therefore, the fixation of such a beneficial allele does not always wipe out DNA variation in the surrounding region. The amount by which variation is reduced largely depends on the initial frequency of the beneficial allele, p. As a consequence, p has a strong effect on the likelihood of detecting the signature of selection during domestication from patterns of polymorphism. These theoretical results are discussed in light of data collected from maize. Although the main focus of this article is on domestication, this model can also be generalized to describe selective sweeps from standing genetic variation.

MeSH Terms
Alleles Crops, Agricultural/genetics Genetics, Population Models, Genetic Polymorphism, Genetic Selection, Genetic Zea mays/genetics
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Innan Hideki
Human Genetics Center, School of Public Health, University of Texas Health Science Center, Houston, TX 77030, USA. [email protected]
Kim Yuseob
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.0401720101
Email
[email protected]
Published
2004-07-20
Epub
2004-00-12
Pages
10667-72
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC489992
Subset
IM
Grants
NIGMS NIH HHS · 2R01 GM51932-06A1 · United States
External Links
PubMed source DOI: 10.1073/pnas.0401720101 PMC Full Text View journal details
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