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PMID: 15258771 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Blood-brain barrier disruption in the hypothalamus of young adult spontaneously hypertensive rats.

Histochemistry and cell biology ·Vol. 122 ·No. 2 ·2004-08-00 ·Pages 131-7

Ueno M, Sakamoto H, Liao YJ, Onodera M, Huang CL, Miyanaka H, Nakagawa T

Abstract

Vascular permeability and endothelial glycocalyx were examined in young adult spontaneously hypertensive rats (SHR), stroke-prone SHR (SHRSP), and Wistar Kyoto rats (WKY) as a control, in order to determine earlier changes in the blood-brain barrier (BBB) in the hypothalamus in chronic hypertension. These rats were injected with horseradish peroxidase (HRP) as an indicator of vascular permeability. Brain slices were developed with a chromogen and further examined with cationized ferritin, a marker for evaluating glycocalyx. Staining for HRP was seen around vessels in the hypothalamus of SHR and SHRSP, but was scarce in WKY. The reaction product of HRP appeared in the abluminal pits of endothelial cells and within the basal lamina of arterioles, showing increased vascular permeability in the hypothalamus of SHR and SHRSP, whereas there were no leaky vessels in the frontal cortex of SHR and SHRSP, or in both areas of WKY. The number of cationized ferritin particles binding to the capillary endothelial cells was decreased in the hypothalamus of SHR and SHRSP, while the number decreased in the frontal cortex of SHRSP, compared with those in WKY. Cationized ferritin binding was preserved in some leaky arterioles, while it was scarce or disappeared in other leaky vessels. These findings suggest that BBB disruption occurs in the hypothalamus of 3-month-old SHR and SHRSP, and that endothelial glycocalyx is markedly damaged there without a close relationship to the early changes in the BBB.

MeSH Terms
Animals Blood Pressure/physiology Blood-Brain Barrier/physiology Cell Membrane Permeability/physiology Endothelial Cells/physiology Ferritins/metabolism Glycocalyx/physiology Histocytochemistry Horseradish Peroxidase Hypertension/genetics,physiopathology Hypothalamus/physiology Male Median Eminence Microscopy, Electron Rats Rats, Inbred SHR Rats, Inbred WKY
Chemicals
Ferritins Horseradish Peroxidase
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Ueno Masaki
Department of Pathology and Host Defense, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, 761-0793, Kagawa, Japan. [email protected],jp
Sakamoto Haruhiko
Liao Ying-Jun
Onodera Masayuki
Huang Cheng-Long
Miyanaka Hiroshi
Nakagawa Toshitaka
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Article Info
Journal
Histochemistry and cell biology
Abbr.
Histochem Cell Biol
ISSN
0948-6143
Published
2004-08-00
Epub
2004-00-17
Pages
131-7
Language
English
Region
Germany
NLM ID
9506663
Subset
IM
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