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PMID: 15282395 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Acute effects of cigarette smoke on inflammation and oxidative stress: a review.

Thorax ·Vol. 59 ·No. 8 ·2004-08-00 ·Pages 713-21

van der Vaart H, Postma DS, Timens W, ten Hacken NH

Abstract

Compared with the effects of chronic smoke exposure on lung function and airway inflammation, there are few data on the acute effects of smoking. A review of the literature identified 123 studies investigating the acute effects of cigarette smoking on inflammation and oxidative stress in human, animal, and in vitro models. An acute smoking model is a relatively easy and sensitive method of investigating the specific effects of cigarette smoke on oxidative stress and inflammation. Acute smoke exposure can result in tissue damage, as suggested by increased products of lipid peroxidation and degradation products of extracellular matrix proteins. Acute cigarette smoke has a suppressive effect on the number of eosinophils and several inflammatory cytokines, possibly due to the anti-inflammatory effect of carbon monoxide. An acute smoking model can supplement other ways of studying the effects of smoking and is an as yet underinvestigated method for intervention studies in smoking related diseases.

MeSH Terms
Acute Disease Bronchitis/etiology,physiopathology Bronchoalveolar Lavage Fluid/cytology Humans Models, Biological Neutrophils/pathology Oxidative Stress/physiology Smoke/adverse effects Smoking/adverse effects
Chemicals
Smoke
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
van der Vaart H
Department of Pulmonology, University Hospital Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands. [email protected]
Postma D S
Timens W
ten Hacken N H T
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Article Info
Journal
Thorax
Abbr.
Thorax
ISSN
0040-6376
DOI
10.1136/thx.2003.012468
Email
[email protected]
Published
2004-08-00
Pages
713-21
Language
English
Region
England
NLM ID
0417353
PMCID
PMC1747102
Subset
IM
External Links
PubMed source DOI: 10.1136/thx.2003.012468 PMC Full Text View journal details
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