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PMID: 15288006 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

Interferon induced Autoimmune Thyroid Disease (AITD): a model for human autoimmunity.

Autoimmunity reviews ·Vol. 3 ·No. 5 ·2004-07-00 ·Pages 388-93

Oppenheim Y, Ban Y, Tomer Y

Abstract

Interferon (IFN) alpha treatment for various conditions has been associated with thyroid autoimmunity. The incidence of interferon induced thyroid autoimmunity has been reported to range from 2.5% to 42%, possibly depending upon dose and duration of medical therapy and patient characteristics. It is not known whether IFN-alpha initiates autoimmune thyroid disease (AITD) or simply exacerbates AITD in individuals with subclinical AITD.

MeSH Terms

Animals Antiviral Agents/adverse effects Disease Models, Animal Humans Interferons/adverse effects Risk Factors Thyroiditis, Autoimmune/chemically induced,immunology

Chemicals

Antiviral Agents Interferons

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Oppenheim Yael

Division of Endocrinology, Diabetes, and Bone Diseases, Mount Sinai School of Medicine, P.O. Box 1055, One Gustave L. Levy Place, New York, NY 10029, USA.

Ban Yoshiyuki

Tomer Yaron

Article Info

Journal

Autoimmunity reviews

Abbr.

Autoimmun Rev

ISSN

1568-9972

DOI

10.1016/j.autrev.2004.03.003

Published

2004-07-00

Pages

388-93

Language

English

Region

Netherlands

NLM ID

101128967

Subset

Grants

NIDDK NIH HHS · DK58072 · United States

NIDDK NIH HHS · DK61659 · United States

External Links

PubMed source DOI: 10.1016/j.autrev.2004.03.003 View journal details

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Interferon induced Autoimmune Thyroid Disease (AITD): a model for human autoimmunity.

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