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PMID: 15300010 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Review

Notch signaling in mammary development and oncogenesis.

Journal of mammary gland biology and neoplasia ·Vol. 9 ·No. 2 ·2004-04-00 ·Pages 145-63

Callahan R, Egan SE

Abstract

With the discovery of an activated Notch oncogene as a causative agent in mouse mammary tumor virus induced breast cancer in mice, the potential role for Notch signaling in normal and pathological mammary development was revealed. Subsequently, Notch receptors have been found to regulate normal development in many organ systems. In addition, inappropriate Notch signaling has been implicated in cancer of several tissues in humans and animal model systems. Here we review important features of the Notch system, and how it may regulate development and cancer in the mammary gland. A large body of literature from studies in Drosophila and C. elegans has not only revealed molecular details of how the Notch proteins signal to control biology, but shown that Notch receptor activation helps to define how other signaling pathways are interpreted. In many ways the Notch system is used to define the context in which other pathways function to control proliferation, differentiation, cell survival, branching morphogenesis, asymmetric cell division, and angiogenesis--all processes which are critical for normal development and function of the mammary gland.

MeSH Terms
Animals Breast/embryology Breast Neoplasms/etiology Gene Expression Regulation Glycosylation Humans Mammary Glands, Animal/embryology Mammary Neoplasms, Animal/etiology Mammary Tumor Virus, Mouse/genetics Membrane Proteins/physiology RNA Splicing Receptors, Notch Signal Transduction/physiology Transcription, Genetic Ubiquitin/metabolism
Chemicals
Membrane Proteins Receptors, Notch Ubiquitin
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Callahan Robert
Mammary Biology and Tumorigenesis Laboratory, National Cancer Institute, Bethesda, Maryland 20892, USA. [email protected]
Egan Sean E
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Article Info
Journal
Journal of mammary gland biology and neoplasia
Abbr.
J Mammary Gland Biol Neoplasia
ISSN
1083-3021
DOI
10.1023/B:JOMG.0000037159.63644.81
Email
[email protected]
Published
2004-04-00
Pages
145-63
Language
English
Region
United States
NLM ID
9601804
Subset
IM
External Links
PubMed source DOI: 10.1023/B:JOMG.0000037159.63644.81 View journal details
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