Adaptive response to alkylating agents involves alteration in situ of O6-methylguanine residues in DNA.

Adaptation, Physiological/drug effects Alkylation/drug effects DNA Damage/drug effects DNA, Bacterial/chemistry,drug effects,metabolism Drug Resistance, Bacterial Escherichia coli/drug effects,enzymology,genetics,metabolism Escherichia coli Proteins/genetics Guanine/analogs & derivatives,metabolism Methylnitronitrosoguanidine/pharmacology Mutagens/pharmacology Mutation/genetics O(6)-Methylguanine-DNA Methyltransferase Transcription Factors

DNA, Bacterial Escherichia coli Proteins Mutagens Transcription Factors Methylnitronitrosoguanidine Guanine O-(6)-methylguanine Ada protein, E coli O(6)-Methylguanine-DNA Methyltransferase