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PMID: 1531813 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Gamma interferon and interleukin 2, but not interleukin 4, are detectable in gamma/delta T-cell cultures after activation with bacteria.

Infection and immunity ·Vol. 60 ·No. 3 ·1992-03-00 ·Pages 1229-31

Follows GA, Munk ME, Gatrill AJ, Conradt P, Kaufmann SH

Abstract

Mycobacterium tuberculosis- or group A streptococcus-activated gamma/delta T cells from normal healthy individuals were negatively sorted and restimulated in vitro from 48 h. Significant amounts of gamma interferon were detected after restimulation with M. tuberculosis, group A streptococci, or Listeria monocytogenes. In contrast, interleukin 4 was undetectable in the culture supernatants. Our findings provide indirect evidence for the involvement of gamma/delta T cells in immunity against tubercle bacilli and probably other bacteria.

MeSH Terms
Cells, Cultured Humans Interferon-gamma/biosynthesis Interleukin-2/biosynthesis Interleukin-4/biosynthesis Listeria monocytogenes/immunology Lymphocyte Activation Mycobacterium tuberculosis/immunology Receptors, Antigen, T-Cell, gamma-delta/analysis Streptococcus pyogenes/immunology T-Lymphocytes/immunology,metabolism
Chemicals
Interleukin-2 Receptors, Antigen, T-Cell, gamma-delta Interleukin-4 Interferon-gamma
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Follows G A
Department of Immunology, University of Ulm, Germany.
Munk M E
Gatrill A J
Conradt P
Kaufmann S H
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.60.3.1229-1231.1992
Published
1992-03-00
Pages
1229-31
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC257618
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.60.3.1229-1231.1992 PMC Full Text View journal details
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