Home LiteratureArticle Details
PMID: 15322881 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Integration and channeling of calcium signaling through the CBL calcium sensor/CIPK protein kinase network.

Planta ·Vol. 219 ·No. 6 ·2004-10-00 ·Pages 915-24

Batistic O, Kudla J

Abstract

Plant development and reproduction depend on a precise recognition of environmental conditions and the integration of this information with endogenous metabolic and developmental cues. Calcium ions have been firmly established as ubiquitous second messengers functioning in these processes. Calcium signal deciphering and signal-response coupling often involve calcium-binding proteins as responders or relays in this information flow. Here we review the calcineurin B-like protein (CBL) calcium sensor/CBL-interacting protein kinase (CIPK) network as a newly emerging signaling system mediating a complex array of environmental stimuli. We focus particularly on the mechanisms generating signaling specificity. Moreover, we emphasize the functional implications that are emerging from the analyses of CBL and CIPK loss-of-function mutants.

MeSH Terms
Calcium/physiology Calcium-Binding Proteins/genetics,physiology Gene Expression Regulation, Plant Genes, Plant Multigene Family Plant Physiological Phenomena Plant Proteins/genetics,physiology Protein Kinases/genetics,physiology Signal Transduction/physiology
Chemicals
Calcium-Binding Proteins Plant Proteins Protein Kinases Calcium
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Batistic Oliver
Institut für Botanik und Botanischer Garten, Universität Münster, Schlossgarten 3, 48149 Münster, Germany.
Kudla Jörg
References (49)
49 references, click to expand
  1. Diverse response of rice and maize genes encoding homologs of WPK4, an SNF1-related protein kinase from wheat, to light, nutrients, low temperature and cytokinins.
    Mol Gen Genet. 2000 Mar;263(2):359-66 PMID: 10778756
  2. Constitutive activation and transgenic evaluation of the function of an arabidopsis PKS protein kinase.
    J Biol Chem. 2002 Nov 1;277(44):42088-96 PMID: 12198122
  3. Calcium sensors and their interacting protein kinases: genomics of the Arabidopsis and rice CBL-CIPK signaling networks.
    Plant Physiol. 2004 Jan;134(1):43-58 PMID: 14730064
  4. Dissecting calcium oscillators in plant cells.
    Trends Plant Sci. 2001 Sep;6(9):395-7 PMID: 11544110
  5. The crystal structure of the novel calcium-binding protein AtCBL2 from Arabidopsis thaliana.
    J Biol Chem. 2003 Oct 24;278(43):42240-6 PMID: 12871972
  6. Network biology: understanding the cell's functional organization.
    Nat Rev Genet. 2004 Feb;5(2):101-13 PMID: 14735121
  7. Reconstitution in yeast of the Arabidopsis SOS signaling pathway for Na+ homeostasis.
    Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):9061-6 PMID: 12070350
  8. Calcium at the crossroads of signaling.
    Plant Cell. 2002;14 Suppl:S401-17 PMID: 12045291
  9. Genes for calcineurin B-like proteins in Arabidopsis are differentially regulated by stress signals.
    Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4718-23 PMID: 10200328
  10. The calcium sensor CBL1 integrates plant responses to abiotic stresses.
    Plant J. 2003 Nov;36(4):457-70 PMID: 14617077
  11. Biochemical characterization of the Arabidopsis protein kinase SOS2 that functions in salt tolerance.
    Plant Physiol. 2002 Sep;130(1):256-64 PMID: 12226505
  12. Transcript profiling coupled with spatial expression analyses reveals genes involved in distinct developmental stages of an arbuscular mycorrhizal symbiosis.
    Plant Cell. 2003 Sep;15(9):2106-23 PMID: 12953114
  13. Comprehensive analysis of gene expression in Nicotiana tabacum leaves acclimated to oxidative stress.
    Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10870-5 PMID: 12122207
  14. Communicating with calcium
    Plant Cell. 1999 Apr;11(4):691-706 PMID: 10213787
  15. Genetic analysis of salt tolerance in arabidopsis. Evidence for a critical role of potassium nutrition.
    Plant Cell. 1998 Jul;10(7):1181-91 PMID: 9668136
  16. The on-off story of protein palmitoylation.
    Trends Cell Biol. 2003 Jan;13(1):32-42 PMID: 12480338
  17. Expression, activation, and biochemical properties of a novel Arabidopsis protein kinase.
    Plant Physiol. 2002 May;129(1):225-34 PMID: 12011353
  18. Biochemical and functional characterization of PKS11, a novel Arabidopsis protein kinase.
    J Biol Chem. 2002 Aug 2;277(31):28340-50 PMID: 12029080
  19. The role of stomata in sensing and driving environmental change.
    Nature. 2003 Aug 21;424(6951):901-8 PMID: 12931178
  20. Calcium/calmodulin-mediated signal network in plants.
    Trends Plant Sci. 2003 Oct;8(10):505-12 PMID: 14557048
  21. The calcium sensor calcineurin B-like 9 modulates abscisic acid sensitivity and biosynthesis in Arabidopsis.
    Plant Cell. 2004 Jul;16(7):1912-24 PMID: 15208400
  22. Calcium oscillations in higher plants.
    Curr Opin Plant Biol. 2001 Oct;4(5):415-20 PMID: 11597499
  23. A calcium sensor homolog required for plant salt tolerance.
    Science. 1998 Jun 19;280(5371):1943-5 PMID: 9632394
  24. Novel protein kinases associated with calcineurin B-like calcium sensors in Arabidopsis.
    Plant Cell. 1999 Dec;11(12):2393-405 PMID: 10590166
  25. CIPK3, a calcium sensor-associated protein kinase that regulates abscisic acid and cold signal transduction in Arabidopsis.
    Plant Cell. 2003 Feb;15(2):411-23 PMID: 12566581
  26. A novel domain in the protein kinase SOS2 mediates interaction with the protein phosphatase 2C ABI2.
    Proc Natl Acad Sci U S A. 2003 Sep 30;100(20):11771-6 PMID: 14504388
  27. The neuronal calcium sensor family of Ca2+-binding proteins.
    Biochem J. 2001 Jan 1;353(Pt 1):1-12 PMID: 11115393
  28. Mindless mastery.
    Nature. 2002 Feb 21;415(6874):841 PMID: 11859344
  29. Regulation of SOS1, a plasma membrane Na+/H+ exchanger in Arabidopsis thaliana, by SOS2 and SOS3.
    Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8436-41 PMID: 12034882
  30. Signal processing and transduction in plant cells: the end of the beginning?
    Nat Rev Mol Cell Biol. 2001 Apr;2(4):307-14 PMID: 11283728
  31. Abiotic stress signalling pathways: specificity and cross-talk.
    Trends Plant Sci. 2001 Jun;6(6):262-7 PMID: 11378468
  32. Calcium: just a chemical switch?
    Curr Opin Plant Biol. 2003 Oct;6(5):500-6 PMID: 12972052
  33. CBL1, a calcium sensor that differentially regulates salt, drought, and cold responses in Arabidopsis.
    Plant Cell. 2003 Aug;15(8):1833-45 PMID: 12897256
  34. Calmodulins and calcineurin B-like proteins: calcium sensors for specific signal response coupling in plants.
    Plant Cell. 2002;14 Suppl:S389-400 PMID: 12045290
  35. EF-hand calcium-binding proteins.
    Curr Opin Struct Biol. 2000 Dec;10(6):637-43 PMID: 11114499
  36. Interaction specificity of Arabidopsis calcineurin B-like calcium sensors and their target kinases.
    Plant Physiol. 2000 Dec;124(4):1844-53 PMID: 11115898
  37. A defined range of guard cell calcium oscillation parameters encodes stomatal movements.
    Nature. 2001 Jun 28;411(6841):1053-7 PMID: 11429606
  38. Molecular characterization of functional domains in the protein kinase SOS2 that is required for plant salt tolerance.
    Plant Cell. 2001 Jun;13(6):1383-400 PMID: 11402167
  39. Cell signaling during cold, drought, and salt stress.
    Plant Cell. 2002;14 Suppl:S165-83 PMID: 12045276
  40. The Arabidopsis CDPK-SnRK superfamily of protein kinases.
    Plant Physiol. 2003 Jun;132(2):666-80 PMID: 12805596
  41. An Arabidopsis SNF1-related protein kinase, AtSR1, interacts with a calcium-binding protein, AtCBL2, of which transcripts respond to light.
    Plant Cell Physiol. 2001 Sep;42(9):976-81 PMID: 11577192
  42. The NAF domain defines a novel protein-protein interaction module conserved in Ca2+-regulated kinases.
    EMBO J. 2001 Mar 1;20(5):1051-63 PMID: 11230129
  43. The biology and enzymology of protein N-myristoylation.
    J Biol Chem. 2001 Oct 26;276(43):39501-4 PMID: 11527981
  44. SOS3 function in plant salt tolerance requires N-myristoylation and calcium binding.
    Plant Cell. 2000 Sep;12(9):1667-78 PMID: 11006339
  45. The Arabidopsis SOS2 protein kinase physically interacts with and is activated by the calcium-binding protein SOS3.
    Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3735-40 PMID: 10725350
  46. The role of calcium and activated oxygens as signals for controlling cross-tolerance.
    Trends Plant Sci. 2000 Jun;5(6):241-6 PMID: 10838614
  47. Conservation and innovation in plant signaling pathways.
    Cell. 2000 Oct 13;103(2):201-9 PMID: 11057894
  48. Calcium-dependent protein kinases play an essential role in a plant defence response.
    EMBO J. 2001 Oct 15;20(20):5556-67 PMID: 11597999
  49. The Arabidopsis thaliana SOS2 gene encodes a protein kinase that is required for salt tolerance.
    Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3730-4 PMID: 10725382
Article Info
Journal
Planta
Abbr.
Planta
ISSN
0032-0935
DOI
10.1007/s00425-004-1333-3
Published
2004-10-00
Epub
2004-00-20
Pages
915-24
Language
English
Region
Germany
NLM ID
1250576
Subset
IM
External Links
PubMed source DOI: 10.1007/s00425-004-1333-3 View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2