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PMID: 15340158 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Changes in connectivity profiles define functionally distinct regions in human medial frontal cortex.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 101 ·No. 36 ·2004-09-07 ·Pages 13335-40

Johansen-Berg H, Behrens TE, Robson MD, Drobnjak I, Rushworth MF, Brady JM, Smith SM, Higham DJ, Matthews PM

Abstract

A fundamental issue in neuroscience is the relation between structure and function. However, gross landmarks do not correspond well to microstructural borders and cytoarchitecture cannot be visualized in a living brain used for functional studies. Here, we used diffusion-weighted and functional MRI to test structure-function relations directly. Distinct neocortical regions were defined as volumes having similar connectivity profiles and borders identified where connectivity changed. Without using prior information, we found an abrupt profile change where the border between supplementary motor area (SMA) and pre-SMA is expected. Consistent with this anatomical assignment, putative SMA and pre-SMA connected to motor and prefrontal regions, respectively. Excellent spatial correlations were found between volumes defined by using connectivity alone and volumes activated during tasks designed to involve SMA or pre-SMA selectively. This finding demonstrates a strong relationship between structure and function in medial frontal cortex and offers a strategy for testing such correspondences elsewhere in the brain.

MeSH Terms
Adult Female Frontal Lobe/anatomy & histology,physiology Humans Magnetic Resonance Imaging Male
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Johansen-Berg H
Oxford Centre for Functional Magnetic Resonance Imaging of the Brain, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom. [email protected]
Behrens T E J
Robson M D
Drobnjak I
Rushworth M F S
Brady J M
Smith S M
Higham D J
Matthews P M
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.0403743101
Email
[email protected]
Published
2004-09-07
Epub
2004-00-30
Pages
13335-40
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC516567
Subset
IM
Grants
Medical Research Council · G9409531 · United Kingdom
External Links
PubMed source DOI: 10.1073/pnas.0403743101 PMC Full Text View journal details
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